{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:45:13Z","timestamp":1791945913206,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Serotonergic and dopaminergic pathways are implicated in Parkinson's disease psychosis (PDP), but preliminary evidence also implicates the endocannabinoid system (ECS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      We examined the association of gray matter volume loss in\n                      <jats:styled-content style=\"fixed-case\">PDP<\/jats:styled-content>\n                      patients with brain expression of the genes coding for\n                      <jats:styled-content style=\"fixed-case\">CB1 (<\/jats:styled-content>\n                      cannabinoid type 1\n                      <jats:styled-content style=\"fixed-case\">)<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">CB2<\/jats:styled-content>\n                      cannabinoid receptors obtained from an independent sample.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Hedges'\n                      <jats:italic>g<\/jats:italic>\n                      effect sizes indexing gray matter volume loss were extracted from a previous meta\u2010analytic comparison of\n                      <jats:styled-content style=\"fixed-case\">PDP<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      without psychosis. The relationship of cortical and subcortical\n                      <jats:styled-content style=\"fixed-case\">CB1<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">CB2<\/jats:styled-content>\n                      gene expression in 6 healthy individuals extracted from the Allen Human Brain Atlas with meta\u2010analytic estimates of\n                      <jats:styled-content style=\"fixed-case\">PDP<\/jats:styled-content>\n                      \u2010related volume loss was examined correcting for spatial autocorrelation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a significant association between gray matter volume loss in\n                      <jats:styled-content style=\"fixed-case\">PDP<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">CB1<\/jats:styled-content>\n                      (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.337,\n                      <jats:italic>t<\/jats:italic>\n                      (76)\u2009=\u20093.122,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) but not\n                      <jats:styled-content style=\"fixed-case\">CB2<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.132, corrected) receptor brain expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This finding underscores the importance of investigating the role of the ECS in\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      . \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70222","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:57:41Z","timestamp":1771581461000},"page":"1566-1571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gray Matter Volume Loss in Parkinson's Disease Psychosis and Cannabinoid Receptor Gene Expression in the Brain"],"prefix":"10.1002","volume":"41","author":[{"given":"Sara","family":"Pisani","sequence":"first","affiliation":[{"name":"Department of Psychosis Studies Institute of Psychiatry, Psychology &amp; Neuroscience, King's College London  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