{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:45:11Z","timestamp":1791945911474,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008750","name":"Shanghai Municipal Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC2023CRD005"],"award-info":[{"award-number":["SHDC2023CRD005"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Parkinson's disease (PD) involves heterogeneous neurodegenerative processes across brain cell types. The cell\u2010type\u2010specific effects of genetic risk remain unclear.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n We aimed to identify cell\u2010type\u2010specific causal genes for PD and to link genetic risk to molecular mechanisms and therapeutic opportunities.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We performed the first cell\u2010stratified Mendelian randomization integrating single\u2010cell expression quantitative trait loci data from eight brain cell types with large\n PD<\/jats:styled-content>\n genome\u2010wide association studies datasets, followed by validation, neuropathological correlation, and postmortem expression analyses.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Thirteen significant causal associations for four genes (\n \n ARL17A<\/jats:italic>\n <\/jats:styled-content>\n ,\n \n ARL17B<\/jats:italic>\n <\/jats:styled-content>\n ,\n \n KANSL1<\/jats:italic>\n <\/jats:styled-content>\n ,\n \n LRRC37A<\/jats:italic>\n <\/jats:styled-content>\n ) were identified across seven cell types, with consistent replication.\n \n ARL17A<\/jats:italic>\n <\/jats:styled-content>\n increased risk, whereas\n \n ARL17B<\/jats:italic>\n <\/jats:styled-content>\n ,\n \n KANSL1<\/jats:italic>\n <\/jats:styled-content>\n , and\n \n LRRC37A<\/jats:italic>\n <\/jats:styled-content>\n were protective. Gene expression correlated with disease severity and showed cell\u2010type\u2010specific dysregulation. Drug\u2013gene interaction screen highlighted US Food and Drug Administration\u2013approved agents including raloxifene and dorzolamide as potential therapeutic modulators.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This study contributed to cell\u2010type\u2010specific genetic mechanisms in\n PD<\/jats:styled-content>\n , linking risk variants to molecular alterations and nominating therapeutic targets. \u00a9 2026 International Parkinson and Movement Disorder Society.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mds.70223","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:15:42Z","timestamp":1770974142000},"page":"1572-1579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cell\u2010Type\u2010Specific Causal Inference Unveils Novel Targets for Parkinson's Disease"],"prefix":"10.1002","volume":"41","author":[{"given":"Si\u2010Chun","family":"Gu","sequence":"first","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao Yang","family":"Sun","sequence":"additional","affiliation":[{"name":"National Neuroscience Institute Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Yi","family":"Shen","sequence":"additional","affiliation":[{"name":"Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Su","sequence":"additional","affiliation":[{"name":"Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xie","sequence":"additional","affiliation":[{"name":"Huashan Hospital, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can\u2010xing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0251-4163","authenticated-orcid":false,"given":"Zhi\u2010dong","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Neuroscience Institute Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eng King","family":"Tan","sequence":"additional","affiliation":[{"name":"National Neuroscience Institute Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4453-6360","authenticated-orcid":false,"given":"Qing","family":"Ye","sequence":"additional","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine Shanghai 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