{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:28:06Z","timestamp":1790954886047,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NU21\u201004\u201000445"],"award-info":[{"award-number":["NU21\u201004\u201000445"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"The Ministry of Education, Youth and Sports","doi-asserted-by":"publisher","award":["LX22NPO5107"],"award-info":[{"award-number":["LX22NPO5107"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aperiodic spectral broadband power has been described recently as reflecting Parkinson's disease (PD) severity. It has therefore become an increasing focus of research interest in the context of the new adaptive deep brain stimulation (DBS) approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to study the influence of DBS on the main parameters of the aperiodic spectral component of local field potentials (LFPs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      LFPs were recorded from the subthalamic nucleus (STN) in patients with PD (n\u2009=\u200922) during a simple experimental paradigm that included 5\u2009minutes of resting state and a short gait task during DBS OFF and ON conditions (\n                      <jats:italic>off<\/jats:italic>\n                      medication). Classical spectral analysis was performed using fast Fourier transform; the analysis of the aperiodic component was performed by fitting oscillations and a one\u2010over\u2010F approach. In a subset of the patients (n\u2009=\u200914), it was possible to evaluate the symptom progression over time after 1\u2009year by analyzing the control measurement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The severity of hypokinetic\/rigid symptomatology, measured by International Parkinson and Movement Disorders Society Unified Parkinson's Disease Rating Scale, correlated significantly with both of the aperiodic components characteristics of the STN LFPs: the slope and the offset. These parameters were significantly modified by DBS, as evaluated with a Wilcoxon signed\u2010rank test during the resting state and during the gait task. Aperiodic power remained stable over time during the control measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The aperiodic component in LFPs may reflect pathological activity of the neuronal network and might serve as a new potential clinical marker in PD. The variable relation to conventional beta oscillopathy indicates the involvement of multiple neural mechanisms. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70232","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:09:48Z","timestamp":1770973788000},"page":"1163-1172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Local Field Aperiodic Spectral Power Modulated by Deep Brain Stimulation in Parkinson's Disease"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-4342","authenticated-orcid":false,"given":"Martin","family":"Lamo\u0161","sequence":"first","affiliation":[{"name":"Brain and Mind Research Program, Central European Institute of Technology, Masaryk University  Brno Czech Republic"},{"name":"First Department of Neurology Masaryk University School of Medicine, St. Anne's Hospital  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4217-6890","authenticated-orcid":false,"given":"Aneta","family":"\u017d\u00e1\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Brain and Mind Research Program, Central European Institute of Technology, Masaryk University  Brno Czech Republic"},{"name":"Faculty of Medicine, Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9077-2959","authenticated-orcid":false,"given":"David","family":"Ul\u010d\u00e1k","sequence":"additional","affiliation":[{"name":"Brain and Mind Research Program, Central European Institute of Technology, Masaryk University  Brno Czech Republic"},{"name":"Faculty of Medicine, Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5557-9610","authenticated-orcid":false,"given":"Benjamin","family":"Gurka","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Brzuchanski","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"\u0160mahovsk\u00e1","sequence":"additional","affiliation":[{"name":"First Department of Neurology Masaryk University School of Medicine, St. Anne's Hospital  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2691-9122","authenticated-orcid":false,"given":"Martina","family":"Bo\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Brain and Mind Research Program, Central European Institute of Technology, Masaryk University  Brno Czech Republic"},{"name":"First Department of Neurology Masaryk University School of Medicine, St. Anne's Hospital  Brno Czech Republic"},{"name":"Faculty of Medicine, Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060281"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70291-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0128-2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.115"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PARKRELDIS.2015.09.028"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10358"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04717.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23951"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27068"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EXPNEUROL.2008.11.008"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/NER.12348"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDS.29276"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27996"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00772-5"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03196-z"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00656-8"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.08.011"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5459-09.2010"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.07.018"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00744-x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.105988"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.82467"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.12.002"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.05.015"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/156869"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.03.015"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww048"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-021-02381-5"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1790-13.2013"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-017-1719-6"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0165-z"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDS.29415"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/AABC9B"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWW286"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWW308"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45922-8"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.01.024"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2022.08.010"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-11728-9"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-023-00553-6"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/EJN.15774"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NBD.2022.105692"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PARKRELDIS.2023.105397"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/CERCOR\/BHAE186"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00737-8"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001806"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.70232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.70232","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.70232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:05:09Z","timestamp":1779789909000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.70232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/mds.70232"],"URL":"https:\/\/doi.org\/10.1002\/mds.70232","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]},"assertion":[{"value":"2025-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}