{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:54:50Z","timestamp":1792029290988,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Idiopathic rapid eye movement (REM) sleep behavior disorder (IRBD) has been linked to the synucleinopathies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      An 80\u2010year\u2010old man treated with venlafaxine for depression presented with IRBD. Cerebrospinal fluid (CSF)\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010synuclein seeding amplification assay (SAA) was negative. During 16\u2009years of follow up he was diagnosed with dementia with Lewy bodies. He died at the age of 96\u2009years. Neuropathology revealed aging\u2010related tau astrogliopathy, limbic\u2010predominant age\u2010related TDP\u201043 encephalopathy, primary age\u2010related tauopathy, and diffuse small vessel disease. Lewy pathology was nearly absent with isolated neurites confined to the dorsal motor nucleus of the vagus nerve. Brainstem nuclei that modulate REM sleep were spared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      RBD may arise independently of\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010synuclein pathology. In the present case, RBD might be caused by dysregulation of the brainstem REM sleep\u2010related structures due to age\u2010related proteinopathies impairing the limbic system, and venlafaxine overactive monoaminergic transmission. In neuroprotective trials, CSF\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010synuclein SAA may be useful to exclude IRBD patients without synuclein pathology. \u00a9 2026 International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70235","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T10:14:14Z","timestamp":1771409654000},"page":"1586-1592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rapid Eye Movement Sleep Behavior Disorder with Clinical Dementia with Lewy Bodies Phenotype but Lacking Postmortem Central Nervous System Synuclein Pathology: Alternate 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