{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:45:27Z","timestamp":1791945927004,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary brain calcification (PBC) is a genetic disease featuring movement disorders, cognitive impairment, and\/or psychiatric symptoms. Computed tomography (CT) scan identifies brain calcification but poorly correlates with patients' clinical phenotype; the role of magnetic resonance imaging (MRI) is yet undefined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Describing white matter (WM) changes and clinical correlates in PBC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty PBC patients and 50 age\u2010matched controls underwent 3\u2009T brain MRI. Patients also underwent brain CT scan, genetic analysis, and clinical and neuropsychological evaluation. Two patterns of supratentorial WM changes were observed: a leukodystrophic band\u2010like and a scattered vascular\u2010like one that were characterized based on anatomical location and severity. Cerebellar WM alterations were also described. Comparison tests and multivariate analysis were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      WM abnormalities were found in 41\/50 patients and 32\/50 controls. Supratentorial band\u2010like leukopathy was observed in 21\/25 patients with centrum semiovale calcifications, involved the deep\/periventricular regions with intermediate sparing (19\/21), was frequently severe (15\/21), diffuse (10\/21) or with anterior prevalence (10\/21), and mostly associated with\n                      <jats:italic>MYORG<\/jats:italic>\n                      (8\/9) and\n                      <jats:italic>PDGFB<\/jats:italic>\n                      \/\n                      <jats:italic>PDGFRB<\/jats:italic>\n                      (5\/8) mutations. The prevalence and severity of vascular\u2010like scattered abnormalities did not differ between patients and controls. Cerebellar leukopathy was present in 16\/50 patients, being severe in 11\/16, frequently observed in\n                      <jats:italic>MYORG<\/jats:italic>\n                      patients (9\/10), and associated with band\u2010like supratentorial leukopathy (16\/16) and cerebellar hemispheric calcifications. WM involvement correlated with cognitive impairment, parkinsonism, psychiatric disturbances (band\u2010like pattern,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02), and cerebellar symptoms (cerebellar leukopathy,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      WM alterations are frequent in PBC and may be an expression of leukodystrophy\u2010like tissue changes, being a potential imaging biomarker of cognitive impairment, parkinsonism severity, and cerebellar dysfunction. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70249","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:47:46Z","timestamp":1771663666000},"page":"1555-1565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["White Matter Matters: A Magnetic Resonance Imaging Study with Clinical Correlates in Primary Brain Calcification"],"prefix":"10.1002","volume":"41","author":[{"given":"Giovanni","family":"Librizzi","sequence":"first","affiliation":[{"name":"Neuroradiology Unit, DIMED, University of Padova  Padova Italy"},{"name":"Padova Neuroscience Center (PNC) University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2581-8751","authenticated-orcid":false,"given":"Giulia","family":"Bonato","sequence":"additional","affiliation":[{"name":"Padova Neuroscience Center (PNC) University of Padova  Padova Italy"},{"name":"Neurodegenerative Disease Unit, Department of Neuroscience University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Corazza","sequence":"additional","affiliation":[{"name":"Neurodegenerative Disease Unit, Department of Neuroscience University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Guerra","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, DIMED, University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pistonesi","sequence":"additional","affiliation":[{"name":"Neurodegenerative Disease Unit, Department of Neuroscience University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4034-8170","authenticated-orcid":false,"given":"Cinzia","family":"Bertolin","sequence":"additional","affiliation":[{"name":"Clinical Genetics Unit, Azienda Ospedale Universit\u00e0 Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Salviati","sequence":"additional","affiliation":[{"name":"Clinical Genetics Unit, Department of Women and Children's Health University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Antonini","sequence":"additional","affiliation":[{"name":"Padova Neuroscience Center (PNC) University of Padova  Padova Italy"},{"name":"Neurodegenerative Disease Unit, Department of Neuroscience University of Padova  Padova Italy"},{"name":"IRCCS San Camillo  Venice 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