{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:17:56Z","timestamp":1787800676344,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Emerging evidence indicates that dysregulation of monounsaturated fatty acids (MUFAs), synthesized by the enzyme stearoyl\u2010coenzyme A desaturase (SCD), impacts on \u03b1\u2010synuclein pathology in the Parkinson's disease (PD) brain.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The objective of this study was to analyze SCD and MUFA\u2010enriched lipids in the periphery of patients with sporadic PD compared with healthy control subjects.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Serum SCD protein was quantified using enzyme\u2010linked immunosorbent assay in patients with PD (n\u2009=\u200940) and control subjects (n\u2009=\u200941). Lipidomic profiling was performed using liquid chromatography\u2013mass spectrometry and LipidSearch software. Statistical analyses included Mann\u2013Whitney\n U<\/jats:italic>\n tests and Welch's\n t<\/jats:italic>\n tests with false discovery rate (FDR) correction.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n SCD levels were higher in PD (mean\u2009= 1702\u2009pg\/ml) compared with control subjects (1158\u2009pg\/ml;\n P<\/jats:italic>\n \u2009=\u20092.2\u2009\u00d7\u200910\n \u22124<\/jats:sup>\n ; Cohen's\n d<\/jats:italic>\n \u2009=\u20090.73). Lipidomics showed elevated MUFA content in four lipid classes: methylphosphatidylcholine, phosphatidylcholine, dihexosylceramide, and triglycerides (FDR\u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Increased SCD and MUFA\u2010enriched lipids indicate altered membrane and sphingolipid metabolism in PD, consistent with central disease pathology, that present a potential for novel biomarker development for PD. \u00a9 2026 The Author(s).\n Movement Disorders<\/jats:italic>\n published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mds.70264","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T01:42:12Z","timestamp":1773193332000},"page":"2178-2183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevation of Stearoyl\u2010Coenzyme A Desaturase and Monounsaturated Fatty Acids in Parkinson's Disease Serum"],"prefix":"10.1002","volume":"41","author":[{"given":"Finula I.","family":"Isik","sequence":"first","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney Sydney New South Wales Australia"},{"name":"School of Medical Sciences, The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Pickford","sequence":"additional","affiliation":[{"name":"Bioanalytical Mass Spectrometry Facility University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Chua","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney Sydney New South Wales Australia"},{"name":"School of Medical Sciences, The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.G.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Macquarie Medical School, Faculty of Medicine, Health and Human Sciences Macquarie University Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Dzamko","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney Sydney New South Wales Australia"},{"name":"School of Medical Sciences, The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4707-933X","authenticated-orcid":false,"given":"Woojin Scott","family":"Kim","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney Sydney New South Wales Australia"},{"name":"School of Medical Sciences, The University of Sydney Sydney New South Wales 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