{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:45:27Z","timestamp":1791945927053,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson's disease (PD) is a progressive neurodegenerative disorder clinically defined by three cardinal motor symptoms: bradykinesia, rigidity, and tremor. Although the natural history of bradykinesia and rigidity is well described, the evolution of tremor as the disease progresses remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The goal was to clinically characterize long\u2010term trajectories of rest, postural, and action tremor in PD and examine their neural network correlates using longitudinal resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective longitudinal cohort study, we analyzed 93 tremor\u2010positive PD patients (mean disease duration: 3.6\u2009years), each with up to six clinical assessments over 4.2\u2009years. Linear mixed\u2010effects models assessed temporal change in Movement Disorder Society\u2010Unified Parkinson's Disease Rating Scale (MDS\u2010UPDRS) and Fahn\u2013Tolosa\u2013Mar\u00edn Tremor Rating Scale (FTM\u2010TRS) scores. Rs\u2010fMRI data from 30 tremor\u2010affected patients (mean interval, 3.35\u2009years) were analyzed for seed\u2010to\u2013whole\u2010brain connectivity and connectivity between predefined brain regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Bradykinesia (\u03b2\u2009=\u2009+0.09,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and rigidity (\u03b2\u2009=\u2009+0.06,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) worsened, whereas total FTM\u2010TRS scores declined by 0.49 points\/year (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.037), driven by reductions in postural (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and action tremor (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.033); resting tremor remained stable. Rs\u2010fMRI revealed longitudinal changes in cerebellar\u2010 and thalamic\u2010seed\u2010to\u2010whole\u2010brain connectivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Tremor in PD evolves along distinct clinical courses, often stabilizing or improving as other motor features worsen. These findings are consistent with partially adaptive reorganization within tremor\u2010related networks and underscore the importance of identifying patient subtypes with divergent trajectories to inform prognosis and optimize therapy. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70268","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T09:54:18Z","timestamp":1774518858000},"page":"1456-1466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Temporal Dynamics of\n                    <scp>Parkinson's Disease<\/scp>\n                    Tremor: Clinical and Neuroimaging Insights"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9658-618X","authenticated-orcid":false,"given":"Melanie","family":"Suette","sequence":"first","affiliation":[{"name":"Department of Neurology Medical University of Graz  Graz Styria Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Matic","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz  Graz Styria Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1756-1379","authenticated-orcid":false,"given":"Marisa","family":"Koini","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz  Graz Styria Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9699-2959","authenticated-orcid":false,"given":"Lukas","family":"Gattermeyer\u2010Kell","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz  Graz Styria Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5151-5324","authenticated-orcid":false,"given":"Daniela","family":"Kern","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz  Graz Styria Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8403-6227","authenticated-orcid":false,"given":"Petra","family":"Katschnig\u2010Winter","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz  Graz Styria 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