{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:17:53Z","timestamp":1787800673835,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Emerging evidence implicates neuroinflammation in progressive supranuclear palsy (PSP) pathophysiology, with elevated cyto\u2010chemokines suggesting natural killer (NK) cell involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We characterized peripheral NK in PSP (N\u2009=\u200911) versus Parkinson's disease (PD, N\u2009=\u200910) and healthy controls (HC, N\u2009=\u20098) at both immunophenotypic and transcriptional levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PSP patients showed significantly reduced CD3\u2010CD56\u2009+\u2009NK frequency (1.35%\u2009\u00b1\u20090.98%) compared with HC (2.96%\u2009\u00b1\u20091.14%) and PD (2.03%\u2009\u00b1\u20090.86%), specifically affecting the immunoregulatory CD56brightCD16\u2212\/dim subset. PSP NK cells exhibited elevated CX3CR1 expression, suggesting enhanced migratory capacity toward inflamed tissues. Transcriptomic analysis of primary NK cells revealed 208 DEG with significant enrichment in angiogenesis pathways, particularly vascular endothelial growth factor\u2010A (VEGF\u2010A). Plasma VEGF\u2010A measurements demonstrated a disease\u2010specific pattern: inverse correlation with severity in PSP versus direct correlation in PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These findings identify a potentially disease\u2010specific transcriptional signature with repercussions on the cyto\u2010chemokine plasma profile. Further investigation of the NK cell\u2010mediated immune response in PSP may provide new insights into disease mechanisms and open avenues for immunomodulatory therapeutic strategies. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70273","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T10:22:24Z","timestamp":1773742944000},"page":"2201-2206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Natural Killer Subset Changes and Vascular Endothelial Growth Factor\u2010A Plasma Profile in Progressive Supranuclear Palsy: The\n                    <scp>NKscape<\/scp>\n                    Study"],"prefix":"10.1002","volume":"41","author":[{"given":"Marina","family":"Picillo","sequence":"first","affiliation":[{"name":"Neuroscience Section, Department of Medicine and Surgery \u201cScuola Medica Salernitana\u201d University of Salerno  Fisciano Italy"},{"name":"IRCCS SYNLAB SDN  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Basile","sequence":"additional","affiliation":[{"name":"School of Specialization in Clinical Pathology and Clinical Biochemistry University of Salerno  Fisciano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Montella","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d University of Salerno  Fisciano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Lopardo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery 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