{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:45:04Z","timestamp":1791945904425,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Perinatal hypoxic\u2013ischemic encephalopathy (HIE) is a severe condition resulting from impaired oxygen delivery to the developing brain, often leading to both motor deficits and dystonia\u2010dyskinetic syndromes (DDS). In selected cases, deep brain stimulation of the globus pallidus internus (GPi\u2010DBS) may provide a therapeutic option. However, predicting outcomes remains challenging because of clinical heterogeneity and variable responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This retrospective study aims to identify preoperative imaging predictors of GPi\u2010DBS efficacy in patients with DDS secondary to HIE, focusing on putaminal atrophy as a potential criterion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 73 patients with DDS secondary to HIE who underwent GPi\u2010DBS at our institution from 2003 to 2023. Clinical outcomes were assessed using the Burke\u2010Fahn\u2010Marsden Dystonia Rating Scale (BFMDRS) and Barry\u2010Albright Dystonia Scale (BADS) at baseline and up to 15\u2009years post\u2010surgery. Preoperative magnetic resonance imaging scans were qualitatively and quantitatively evaluated to assess putaminal atrophy. Statistical analyses explored the relationships between imaging findings, clinical severity, and DBS outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with severe putaminal atrophy exhibited significantly higher preoperative BFMDRS motor and disability scores, correlating with a limited response to DBS at 1\u2010year follow\u2010up (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Volumetric analysis confirmed that greater putaminal atrophy was associated with poorer motor improvements post\u2010surgery. The predictive value of putaminal volume for long\u2010term outcomes remained significant at 5\u2010year follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Putaminal atrophy is a key predictor of suboptimal outcomes following GPi\u2010DBS in patients with HIE\u2010related DDS. These findings highlight the importance of preoperative imaging in candidate selection and underscore the need for alternative strategies in patients with severe post\u2010anoxic basal ganglia damage. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70275","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:01:07Z","timestamp":1773889267000},"page":"1402-1412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Putamen Atrophy as a Predictive Factor of Efficacy of\n                    <scp>GPi<\/scp>\n                    \u2010\n                    <scp>DBS<\/scp>\n                    in Dystonia\u2010Dyskinesia Syndrome Secondary to Perinatal Anoxic Encephalopathy"],"prefix":"10.1002","volume":"41","author":[{"given":"Marylou","family":"Grasso","sequence":"first","affiliation":[{"name":"Research Unit (URCMA: Unit\u00e9 de Recherche sur les Comportements et Mouvements Anormaux), Centre Hospitalo\u2010Universitaire Gui de Chauliac  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Olivier","family":"Moser","sequence":"additional","affiliation":[{"name":"Research Unit (URCMA: Unit\u00e9 de Recherche sur les Comportements et Mouvements Anormaux), Centre Hospitalo\u2010Universitaire Gui de Chauliac  Montpellier France"},{"name":"Stereotactic and Functional Neurosurgery Unit, D\u00e9partement de neurochirurgie, Unit\u00e9 \u00abPathologie C\u00e9r\u00e9brales R\u00e9sistantes\u00bb, Centre Hospitalo\u2010Universitaire Gui de Chauliac  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidonie","family":"Sauvageot","sequence":"additional","affiliation":[{"name":"Research Unit (URCMA: Unit\u00e9 de Recherche sur les Comportements et Mouvements Anormaux), Centre Hospitalo\u2010Universitaire Gui de Chauliac  Montpellier France"},{"name":"Stereotactic and Functional Neurosurgery Unit, D\u00e9partement de neurochirurgie, Unit\u00e9 \u00abPathologie C\u00e9r\u00e9brales R\u00e9sistantes\u00bb, Centre Hospitalo\u2010Universitaire Gui de Chauliac  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Gil","sequence":"additional","affiliation":[{"name":"Research Unit (URCMA: Unit\u00e9 de Recherche sur les Comportements et Mouvements Anormaux), Centre Hospitalo\u2010Universitaire Gui de Chauliac  Montpellier 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