{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:46:48Z","timestamp":1792597608037,"version":"4.5.0"},"reference-count":6,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,10]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n The association between intronic variable number tandem repeat (VNTR) expansions in intron 10 of the\n HSF1<\/jats:italic>\n gene and essential tremor (ET) has not yet been validated in larger, more diverse populations.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n This study aimed to investigate the association between\n HSF1<\/jats:italic>\n gene VNTR expansions and ET in the population of Eastern China.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We screened 324 patients and 197 healthy controls (HCs) using fluorescence amplicon length analysis polymerase chain reaction (PCR) then precisely identified and analyzed repeat expansions at this locus by combining repeat\u2010primed PCR with long\u2010read whole\u2010genome sequencing.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Despite identifying 18 patients (5.6%) carrying large\n HSF1<\/jats:italic>\n intronic VNTR expansions (>700\u2009bp), our study found no significant difference in the overall distribution of repeat expansion lengths between the entire cohort of 324 ET patients and HCs, nor between familial and sporadic ET subgroups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The amplification of this repetitive sequence in intron 10 of the\n HSF1<\/jats:italic>\n gene does not constitute a universal, major, or reliable genetic risk factor for ET. \u00a9 2026 International Parkinson and Movement Disorder Society.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mds.70282","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:35:02Z","timestamp":1774424102000},"page":"2773-2776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessing Intronic Variable Number Tandem Repeat (\n VNTR)<\/scp>\n Expansions of the\n \n HSF1<\/i>\n <\/scp>\n Gene in Essential Tremor Patients from Eastern China"],"prefix":"10.1002","volume":"41","author":[{"given":"Lanxiao","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine Zhejiang University Yiwu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine Zhejiang University Yiwu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine Zhejiang University Yiwu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine Zhejiang University Yiwu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine Zhejiang University Yiwu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine Zhejiang University Yiwu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing'er","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine Zhejiang University Yiwu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine Zhejiang University Yiwu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine Zhejiang University Yiwu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine Zhejiang University Yiwu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0593-9175","authenticated-orcid":false,"given":"Guohua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine Zhejiang University Yiwu China"},{"name":"Department of Neurology, The Second Affiliated Hospital of School of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf241"},{"issue":"3","key":"e_1_2_9_3_1","first-page":"2","article-title":"Consensus statement of the Movement Disorder Society on tremor. Ad hoc scientific committee","volume":"13","author":"Deuschl G","year":"1998","journal-title":"Mov Disord"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2022.01.012"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2019-106268"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2022.02.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00314-w"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.70282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.70282","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.70282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:55:56Z","timestamp":1792594556000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.70282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,25]]},"references-count":6,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/mds.70282"],"URL":"https:\/\/doi.org\/10.1002\/mds.70282","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,25]]},"assertion":[{"value":"2025-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}