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Theta power (2\u20138 Hz) increased during hyperkinetic states, whereas high beta power (20\u201330 Hz) elevated during hypokinetic states, both correlating significantly with clinical symptom severity. These patterns were not modulated by voluntary movement. Electrophysiological connectivity analysis integrated with neuroimaging analysis showed that globus pallidum externus\u2013globus pallidus internus theta coherence correlated with indirect pathway structural connectivity, whereas pallidal high beta power associated with direct pathway functional connectivity, reflecting HD's dual circuit pathology. Spatial mapping localized theta oscillations to the posterior globus pallidus, with fibers projecting to motor cortical areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We establish an electrophysiological framework explaining HD's complex symptomatology through dual oscillatory signatures. These findings provide circuit\u2010specific biomarkers for disease monitoring and anatomical targets for optimizing deep brain stimulation in patients with HD. \u00a9 2026 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70290","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:34:36Z","timestamp":1775468076000},"page":"1413-1426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual Oscillatory Signatures in Pallidal Circuits Underlie Symptom Complexity in Huntington's Disease Patients"],"prefix":"10.1002","volume":"41","author":[{"given":"Yichen","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Beijing Tiantan Hospital, Capital Medical University  Beijing China"},{"name":"Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences 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