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Idiopathic\/isolated rapid eye movement (REM) sleep behavior disorder (iRBD) represents a prodromal stage of such disorders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To assess [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET as a neurodegeneration biomarker, using published brain metabolic disease\u2010related patterns, and a regional\u2010based approach, across the prodromal to overt\n                      <jats:italic>\u03b1\u2010<\/jats:italic>\n                      synucleinopathy continuum.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We included 83 prodromal subjects with iRBD, comprising non\u2010converters (n\u2009=\u200956) and converters (n\u2009=\u200927) to an overt\n                      <jats:italic>\u03b1\u2010<\/jats:italic>\n                      synucleinopathy (either Parkinson's disease [PD] or dementia with Lewy bodies [DLB]) according to the last available follow\u2010up, and 85 subjects with PD (n\u2009=\u200940) and DLB (n\u2009=\u200945). For comparison, we enrolled a group of healthy subjects (n\u2009=\u200941). Participants underwent brain [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET at baseline. Analysis of covariance was used to test the ability of previously published [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET disease\u2010related patterns in characterizing neurodegeneration levels along the prodromal to overt\n                      <jats:italic>\u03b1\u2010<\/jats:italic>\n                      synucleinopathy continuum, and across the motor\u2010predominant (parkinsonism\u2010first) and the cognitive\u2010predominant (dementia\u2010first) clinical trajectories. We further assessed metabolic changes using a regional\u2010based approach.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All disease\u2010related patterns effectively discriminated clinical stages, from prodromal to overt\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010synucleinopathies, with comparable performance. [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET significantly distinguished all groups along the cognitive\u2010predominant pathway; whereas in the motor\u2010predominant pathway, converter patients were not significantly discriminated from non\u2010converters. Regionally, the inferior parietal, precuneus, and middle frontal areas exhibited the most prominent decrease in [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG uptake with progression, alongside relative parallel progressive increases in the cerebellum, pons, parahippocampal areas, putamen, and pallidum.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET disease\u2010related patterns efficiently characterize neurodegeneration from prodromal to overt\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010synucleinopathy, best assessing the cognitive\u2010predominant (dementia\u2010first) pathway. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70301","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T06:36:37Z","timestamp":1775457397000},"page":"1786-1797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["[\n                    <sup>18<\/sup>\n                    F]Fluorodeoxyglucose positron emission tomography ([\n                    <scp>\n                      <sup>18<\/sup>\n                      F\n                    <\/scp>\n                    ]\n                    <scp>FDG PET)<\/scp>\n                    Characterizes Neurodegeneration Levels Across the\n                    <i>\u03b1\u2010<\/i>\n                    Synucleinopathy Continuum"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9983-7940","authenticated-orcid":false,"given":"Beatrice","family":"Orso","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8877-899X","authenticated-orcid":false,"given":"Ignacio","family":"Roura","sequence":"additional","affiliation":[{"name":"Medical Psychology Unit, Department of Medicine, Institute of Neurosciences University of Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona 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