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accurate understanding of prognosis in Parkinson's disease (PD) is important for patient information provision, personalized treatment, and clinical trial design, but most previous research has been biased towards younger, healthier patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe key clinical outcomes longitudinally and identify baseline prognostic factors (predictors) for these outcomes using population\u2010representative PD cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We meta\u2010analyzed individual patient data from six incidence cohorts in Western Europe (Norway, Sweden, and UK). Each cohort aimed to recruit and follow up all newly diagnosed cases in defined population\/incidence periods (between 2000 and 2011). We described postural instability (Hoehn &amp; Yahr Stage 3), functional dependency (needing help with daily activities), dementia, and death with up to 12\u2009years' follow\u2010up and investigated clinical and genetic predictors using frailty Cox models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 883 population\u2010based incident patients, median age at motor symptom onset was 69.2\u2009years. Median time to postural instability and functional dependency was 7.4\u2009years. Dementia affected 49.6% by 10\u2009years and 54.7% had died by 12\u2009years (median survival 9.4\u2009years). Older age, higher Movement Disorder Society\u2010Unified Parkinson's Disease Rating Scale\u2010Part III (MDS\u2010UPDRS\u2010III) score, and lower Mini\u2010Mental State Examination (MMSE) were significantly associated with all outcomes; cognitive symptoms and\n                      <jats:italic>GBA<\/jats:italic>\n                      polymorphisms with each outcome except mortality; and\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 with increased mortality and dementia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This first individual patient data meta\u2010analysis of population\u2010based incidence cohorts provides robust prognostic data, with fewer selection biases than previous PD studies, for informing people with PD about prognosis. In incidence cohorts, overall PD prognosis is worse than previously suggested, with key outcomes often occurring early. Further work should develop validated prognostic models for objective stratification of prognostic risk and for personalized medicine. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70303","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:40:22Z","timestamp":1775893222000},"page":"1798-1811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prognosis in Parkinson's Disease: An Individual Patient Data Meta\u2010Analysis of Six European Incidence Cohorts"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6284-4239","authenticated-orcid":false,"given":"Angus 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