{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:06:51Z","timestamp":1784678811978,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Optimal outcomes from subthalamic nucleus deep brain stimulation (STN\u2010DBS) for Parkinson's disease (PD) depend on accurate stimulation of an ideal functional target within the dorsolateral STN. Clinical programming is heuristic, and objective methods are needed to improve efficiency and consistency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to investigate the feasibility and acute motor benefit of STN\u2010DBS programming, guided by intraoperatively recorded evoked resonant neural activity (ERNA) in patients with PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed 12 patients with anatomically well\u2010placed leads, 4\u20136\u2009months following STN\u2010DBS. The worst hemibody was tested off\u2010medication. Acute motor benefit was double\u2010blind assessed for three programming configurations: (i) chronic expert clinician settings, (ii) imaging guided, and (iii) an ERNA automated algorithm. We also compared therapeutic and side effect thresholds and the spatial distribution of fractionated current.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ERNA programming improved hemibody Movement Disorder Society\u2010Unified Parkinson's Disease Rating Scale\u2010Part III scores by 75.7% (median) compared with off\u2010stimulation. This was not different from imaging (81.6%,\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.19) or clinician programming (68.8%,\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.33). Therapeutic thresholds (\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.90) and side effect thresholds (\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.57) did not differ across conditions. ERNA programming was 0.8\u20131\u2009mm ventral and 0.3\u2009mm posterior to imaging and clinician programming.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      A programming algorithm based solely on ERNA achieved acute motor efficacy and tolerability equivalent to expert clinical and imaging\u2010based approaches. ERNA recordings took &lt;1\u2009min, under awake and general anesthetic conditions. These findings suggest that intraoperative ERNA can provide a rapid, objective, and practical starting point for STN\u2010DBS programming. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70318","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T02:03:58Z","timestamp":1776305038000},"page":"1847-1855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Automating Subthalamic Deep Brain Stimulation Programming with Evoked Resonant Neural Activity in Parkinson's Disease"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1065-6006","authenticated-orcid":false,"given":"Kanae J.","family":"Nagao","sequence":"first","affiliation":[{"name":"Medical Bionics Department The University of Melbourne  Melbourne Victoria Australia"},{"name":"Florey Department of Neuroscience and Mental Health The University of Melbourne  Melbourne Victoria Australia"},{"name":"Neurology Department Austin Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thushara","family":"Perera","sequence":"additional","affiliation":[{"name":"Medical Bionics Department The University of Melbourne  Melbourne Victoria Australia"},{"name":"Deep Brain Stimulation Technologies Pty Ltd  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Petoe","sequence":"additional","affiliation":[{"name":"Medical Bionics Department The University of Melbourne  Melbourne Victoria Australia"},{"name":"Deep Brain Stimulation Technologies Pty Ltd  Melbourne Victoria Australia"},{"name":"Florey Institute of 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