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Since the discovery of pathogenic variants in the gene encoding \u03b1\u2010synuclein, as well as the finding that \u03b1\u2010synuclein is a major constituent of Lewy pathology, PD is considered as a prototypical synucleinopathy. However, neuropathological studies consistently show that most people with PD display copathologies, many of which are linked to specific clinical features and outcomes. In this review, we summarize the spectrum and frequency of these co\u2010 and multi\u2010pathologies in idiopathic and genetic PD and their impact on disease initiation and progression. 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