{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:18:07Z","timestamp":1787800687672,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","award":["UK DRI\u20105209"],"award-info":[{"award-number":["UK DRI\u20105209"]}],"id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["10116958"],"award-info":[{"award-number":["10116958"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Models trained on accelerometer data have been proposed for detecting prodromal Parkinson's disease (PD). However, uncertainties in diagnosis timing in the UK Biobank (UKBB) may affect generalizability to other cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of the study was to evaluate the performance of previously published models for prodromal PD detection in other international cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We applied the models to data from German and British cohorts of individuals with isolated or idiopathic rapid eye movement sleep behavior disorder and healthy controls. We compared hourly acceleration patterns and classification performance across cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The British cohort exhibited visually similar activity patterns to UK Biobank but weaker statistical differences and reduced model performance. The German cohort showed no significant group differences and lower performance. No pair of cohorts demonstrated statistical equivalence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Models trained on UK Biobank data may capture early clinical disease rather than universal prodromal markers. Prospective validation in well\u2010characterized cohorts is essential before clinical translation. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70329","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T06:19:37Z","timestamp":1778912377000},"page":"2189-2200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wearable Movement\u2010Tracking for Prodromal Parkinson's Disease Detection: A Cross\u2010Country Validation Study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2741-2611","authenticated-orcid":false,"given":"Fabian","family":"Kahl","sequence":"first","affiliation":[{"name":"Institute for Digital Medicine, University of Bonn, University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Kathrin","family":"Schalkamp","sequence":"additional","affiliation":[{"name":"Bakar Computational Health Sciences Institute University of California, San Francisco  San Francisco California USA"},{"name":"UK Dementia Research Institute at Imperial College London  London UK"},{"name":"Department of Brain Sciences Faculty of Medicine, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina Mary","family":"Gunter","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5858-7762","authenticated-orcid":false,"given":"Anja","family":"Ophey","sequence":"additional","affiliation":[{"name":"Medical Psychology | Neuropsychology and Gender Studies, Center for Neuropsychological Diagnostics and Intervention (CeNDI), Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"},{"name":"Cognitive Neuroscience, Institute for Neuroscience and Medicine (INM\u20103), Research Centre Juelich  Juelich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinah","family":"R\u00f6ttgen","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience, Institute for Neuroscience and Medicine (INM\u20103), Research Centre Juelich  Juelich Germany"},{"name":"Department of Neurology Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil","family":"Razzaque","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Kufer","sequence":"additional","affiliation":[{"name":"Clinic for Parkinson's Disease, Sleep Disorders, and Movement Disorders University of Bonn, University Hospital Bonn  Bonn Germany"},{"name":"German Centre for Neurodegenerative Diseases (DZNE)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8905-1052","authenticated-orcid":false,"given":"Cynthia","family":"Sandor","sequence":"additional","affiliation":[{"name":"UK Dementia Research Institute at Imperial College London  London UK"},{"name":"Department of Brain Sciences Faculty of Medicine, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8230-1856","authenticated-orcid":false,"given":"Gereon R.","family":"Fink","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience, Institute for Neuroscience and Medicine (INM\u20103), Research Centre Juelich  Juelich Germany"},{"name":"Department of Neurology Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8603-2545","authenticated-orcid":false,"given":"Elke","family":"Kalbe","sequence":"additional","affiliation":[{"name":"Medical Psychology | Neuropsychology and Gender Studies, Center for Neuropsychological Diagnostics and Intervention (CeNDI), Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Maetzler","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Schleswig\u2010Holstein Campus Kiel and Kiel University  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clint","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Schleswig\u2010Holstein Campus Kiel and Kiel University  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan M.","family":"Jonas","sequence":"additional","affiliation":[{"name":"Institute for Digital Medicine, University of Bonn, University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele T.","family":"Hu","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre University of Oxford 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