{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:16:17Z","timestamp":1791101777473,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment of Parkinson's disease (PD) with levodopa results in a sustained reduction of symptoms. Although the plasma half\u2010life of levodopa is short, it elicits a lasting effect, the long\u2010duration levodopa response (LDR). A decrease in LDR as PD progresses has been linked to motor complications, but long\u2010term data on the LDR and its clinical implications remain scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim is to analyze the magnitude and impact of the LDR over time using data from the Parkinson's Disease Progression Marker Initiative (PPMI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>First, therapy\u2010na\u00efve Movement Disorder Society\u2010Unified Parkinson's Disease Rating Scale part III (MDS\u2010UPDRS III) scores were predicted using a mixed linear model (MLM) from n\u2009=\u2009245 untreated people with PD (PwPD). This model yielded an increase of MDS\u2010UPDRS III scores of 2.65 points per year. Using this model, we then calculated LDR and short\u2010duration response in longitudinal data of 148 initially therapy\u2010na\u00efve PwPD. Symptom progression was analyzed using correlation analyses and MLMs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the 98 PwPD with observed LDR, the LDR accounted for approximately half of the total levodopa response. No significant change in LDR magnitude was observed over up to 10\u2009years (analysis of variance,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.14; generalized estimating equations,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.26). The LDR magnitude was not associated with the onset of motor complications. PwPD with absent LDR (n\u2009=\u200950) progressed faster than PwPD with observed LDR in several motor and non\u2010motor domains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The LDR is a stable component of the levodopa response and needs to be considered in clinical trials. These findings argue against a declining LDR as a major driver of motor fluctuations in PD. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70344","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T11:06:51Z","timestamp":1778324811000},"page":"2033-2041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010Duration Response to Levodopa in the\n                    <scp>PPMI<\/scp>\n                    \u2010Cohort"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0870-8105","authenticated-orcid":false,"given":"Nils","family":"Schnalke","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical Faculty and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"},{"name":"Center for Neurodegenerative Diseases within the Helmholtz Association (DZNE)  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Feige","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases within the Helmholtz Association (DZNE)  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-2399","authenticated-orcid":false,"given":"Tom","family":"H\u00e4hnel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Falkenburger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"},{"name":"Center for Neurodegenerative Diseases within the Helmholtz Association (DZNE)  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14094"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-022-02511-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-023-02627-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00712-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-022-00439-z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209137"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03101-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.09.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.705407"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2202867"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2024.107257"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196702162760703"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.03.014"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa181"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29659"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27790"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10189"},{"key":"e_1_2_9_19_1","unstructured":"PPMI 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