{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:34:27Z","timestamp":1791491667066,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["06170676"],"award-info":[{"award-number":["06170676"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Although clinical markers (eg, motor and cognitive impairment) in isolated rapid eye movement sleep behavior disorder (\n iRBD<\/jats:styled-content>\n ) are associated with faster phenoconversion, their longitudinal trajectory patterns (linear or nonlinear) remain unclear. Additionally, evidence regarding the magnitude of neurodegenerative risk in\n iRBD<\/jats:styled-content>\n compared to non\u2010\n RBD<\/jats:styled-content>\n individuals remains limited.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n The aim was to investigate longitudinal changes in clinical markers and assess the magnitude of neurodegenerative risk in\n iRBD<\/jats:styled-content>\n versus non\u2010\n RBD<\/jats:styled-content>\n subjects.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this prospective matched cohort study, video\u2010polysomnography\u2010confirmed\n iRBD<\/jats:styled-content>\n patients and age\u2010 and sex\u2010matched non\u2010\n RBD<\/jats:styled-content>\n subjects were followed every 1.5\u20132\u2009years to evaluate neurodegenerative outcomes and markers. Longitudinal marker changes and neurodegenerative risk between groups were compared.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One\u2010hundred thirty\u2010three\n iRBD<\/jats:styled-content>\n patients and 101 non\u2010\n RBD<\/jats:styled-content>\n subjects were followed for a mean of 6.9\u2009\u00b1\u20092.9\u2009years. Parkinsonism\u2010first converters were associated with motor dysfunction, whereas dementia\u2010first converters were associated with cognitive, motor, olfactory, and color vision dysfunctions. Motor and global cognitive functions exhibited nonlinear progression in\n iRBD<\/jats:styled-content>\n , with marked acceleration before parkinsonism or dementia diagnosis. Conversion rates in\n iRBD<\/jats:styled-content>\n patients were 4.7% at 3\u2009years, 30.1% at 7\u2009years, and 79.5% at 13\u2009years, exceeding those in non\u2010\n RBD<\/jats:styled-content>\n subjects (3% at 3\u2009years and 16.1% at 13\u2009years).\n iRBD<\/jats:styled-content>\n patients had a higher neurodegeneration risk (hazard ratio [95% confidence interval [\n CI<\/jats:styled-content>\n ]: 9.6 [3.8, 23.8],\n P<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Motor and global cognition demonstrate nonlinear accelerating progressions during\n iRBD<\/jats:styled-content>\n phenoconversion.\n iRBD<\/jats:styled-content>\n carries a nearly 10\u2010fold higher risk of future neurodegeneration than non\u2010\n RBD<\/jats:styled-content>\n subjects. These findings highlighted a critical window for risk stratification and early intervention before neurodegenerative disease onset in\n iRBD<\/jats:styled-content>\n . \u00a9 2026 The Author(s).\n Movement Disorders<\/jats:italic>\n published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mds.70346","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:36:24Z","timestamp":1777696584000},"page":"2086-2095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Progression of Motor and Cognitive Functions in Isolated\n REM<\/scp>\n Sleep Behavior Disorder: A 7\u2010Year Prospective Matched Cohort Study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2998-0300","authenticated-orcid":false,"given":"Li","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine The Chinese University of Hong Kong Shatin, N.T., Hong Kong SAR China"},{"name":"Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine The Chinese University of Hong Kong Shatin, N.T., Hong Kong SAR China"},{"name":"Department of Medicine Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine The Chinese University of Hong Kong Shatin, N.T., Hong Kong SAR China"},{"name":"Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine The Chinese University of Hong Kong Shatin, N.T., Hong Kong SAR China"},{"name":"Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine The Chinese University of Hong Kong Shatin, N.T., Hong Kong SAR China"},{"name":"Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine The Chinese University of Hong Kong Shatin, N.T., Hong Kong SAR China"},{"name":"Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong Shatin, Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine The Chinese University of Hong Kong Shatin, N.T., Hong Kong SAR 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Medicine The Chinese University of Hong Kong Shatin, N.T., Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joey W.Y.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine The Chinese University of Hong Kong Shatin, N.T., Hong Kong SAR China"},{"name":"Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine The Chinese University of Hong Kong Shatin, N.T., Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy W.M.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine The Chinese University of Hong Kong Shatin, N.T., Hong Kong SAR China"},{"name":"Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine The Chinese University of Hong Kong Shatin, N.T., Hong Kong SAR 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