{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:48:48Z","timestamp":1791791328059,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50DC01990"],"award-info":[{"award-number":["P50DC01990"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Relatively little is known about voice and speech abnormalities and their changes after deep brain stimulation (\n                      <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>\n                      ) in patients with dystonia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim was to determine the incidence of speech abnormalities, including laryngeal dystonia, among patients with dystonia receiving DBS and to characterize their response to this neurosurgical neuromodulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A three\u2010part study, including a retrospective analysis, systematic literature review, and meta\u2010analysis, was completed. Patients with dystonia receiving DBS at Massachusetts General Hospital and the University of California San Francisco between 2004 and 2024 were included in the retrospective study. Those with preoperative voice and speech abnormalities were grouped by type of alterations and response to DBS and evaluated using the Burke\u2013Fahn\u2013Marsden Dystonia Rating Scale (BFMDRS) speech and swallowing subscores. A systematic literature review was conducted for studies of voice and speech outcomes in DBS for dystonia. A meta\u2010analysis of studies reporting BFM speech and swallowing subscores pre\u2010 and post\u2010DBS was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred eighty\u2010three participants received DBS for dystonia, and 34 (18.6%) had baseline voice and speech abnormalities. BFMDRS speech and swallowing subscores improved with DBS in isolated (but not combined) dystonia, driven primarily by two subgroups. Twenty studies were included in the systematic literature review. A majority of included speech measures were unchanged with DBS; a smaller number showed improvement or worsening. Nine studies reporting pre\u2010 and post\u2010DBS BFMDRS speech and swallowing subscores were included in the meta\u2010analysis, which showed improvement with DBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Data are mixed on response of speech to\n                      <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>\n                      in dystonia, though worsening of speech appears rare. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  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Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9885-704X","authenticated-orcid":false,"given":"Marta","family":"San Luciano","sequence":"additional","affiliation":[{"name":"Movement Disorder and Neuromodulation Center, Department of Neurology UCSF Weill Institute for Neurosciences, University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill L.","family":"Ostrem","sequence":"additional","affiliation":[{"name":"Movement Disorder and Neuromodulation Center, Department of Neurology UCSF Weill Institute for Neurosciences, University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole E.","family":"Buie","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Massachusetts Eye and Ear, Harvard Medical School  Boston Massachusetts USA"},{"name":"Program in Speech Hearing Bioscience and Technology Harvard University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Arno","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Massachusetts Eye and Ear, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikayla","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Massachusetts Eye and Ear, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7444-0437","authenticated-orcid":false,"given":"Kristina","family":"Simonyan","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital, Harvard Medical School  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