{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:48:44Z","timestamp":1791791324971,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR203312"],"award-info":[{"award-number":["NIHR203312"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>SUNRISE\u2010PD was a dose\u2010escalating, phase 1\/2 study investigating a second\u2010generation lentiviral vector gene therapy delivering the genes for dopamine synthesis (OXB\u2010102) to treat Parkinson's disease (PD). The trial was prematurely terminated due to insolvency of the sponsor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim was to provide an investigator\u2010led description of the clinical course for the 6 patients enrolled in the OXB\u2010102 trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Individual patient data were extracted, compiled, and summarized from investigator records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six patients received a low (n\u2009=\u20092) and a higher (n\u2009=\u20094) dose of the OXB\u2010102 gene therapy. There were eight serious adverse events (SAE), of which only one was considered definitely related to the intervention. All SAEs were transient and resolved without sequelae. Efficacy data were limited, but some stabilization of motor function was observed in most of the patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This novel dopamine gene therapy appears safe in patients with moderate\u2010to\u2010severe PD, with some possible stabilizing effects on their clinical course. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  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Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Kayhanian","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge Stem Cell Institute University of Cambridge  Cambridge United Kingdom"},{"name":"Department of Neurosurgery Cambridge University Hospitals  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip C.","family":"Buttery","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge Stem Cell Institute University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Cambridge University Hospitals  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Andresen","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge Stem Cell Institute University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sherlock","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge Stem Cell Institute University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Hewitt","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge Stem Cell Institute University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tagore","family":"Nakornchai","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge Stem Cell Institute University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan","family":"Hariz","sequence":"additional","affiliation":[{"name":"UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery  London United Kingdom"},{"name":"Deparment of Clinical Neuroscience Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriacos","family":"Mitrophanous","sequence":"additional","affiliation":[{"name":"Oxford Biomedica (UK) Limited  Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludvic","family":"Zrinzo","sequence":"additional","affiliation":[{"name":"UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Appleby","sequence":"additional","affiliation":[{"name":"UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil","family":"Woodgate","sequence":"additional","affiliation":[{"name":"UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Maru","sequence":"additional","affiliation":[{"name":"UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Limousin","sequence":"additional","affiliation":[{"name":"UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Girges","sequence":"additional","affiliation":[{"name":"UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0752-1813","authenticated-orcid":false,"given":"Thomas","family":"Foltynie","sequence":"additional","affiliation":[{"name":"UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Palfi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Henri Mondor Academic Hospital Universit\u00e9 Paris Est Cr\u00e9teil, GRCT OPTIMA, INSERM Laboratory U955 of Translational NeuroPsychiatry, Institut Mondor de Recherche Biom\u00e9dicale  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Barker","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge Stem Cell Institute 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