{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:48:49Z","timestamp":1791791329498,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171421"],"award-info":[{"award-number":["82171421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371432"],"award-info":[{"award-number":["82371432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371266"],"award-info":[{"award-number":["82371266"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171252"],"award-info":[{"award-number":["82171252"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501508"],"award-info":[{"award-number":["82501508"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272039"],"award-info":[{"award-number":["82272039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82021002"],"award-info":[{"award-number":["82021002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82394434"],"award-info":[{"award-number":["82394434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Corticobasal syndrome (CBS) may arise from heterogeneous neuropathological substrates, including corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and Alzheimer's disease (AD), and biomarker\u2010based stratification has therefore become central to its characterization\n                      <jats:italic>in vivo<\/jats:italic>\n                      . In a large CBS cohort, we examined whether\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010fluorodeoxyglucose (FDG) positron emission tomography (PET) metabolic patterns reflect underlying amyloid\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      deposition and tau topography, and how these patterns relate to the clinical phenotype.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a cross\u2010sectional study of consecutive patients with CBS and were enrolled at Huashan Hospital, Fudan University, between December 2019 and February 2025. Each patient underwent\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET for cerebral glucose metabolism, amyloid status assessment using amyloid PET or cerebrospinal fluid biomarkers, and florzolotau(\n                      <jats:sup>18<\/jats:sup>\n                      F) PET for tau topography.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 113 patients,\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET identified five distinct metabolic subgroups: AD type (n\u2009=\u200920), CBD type I (n\u2009=\u200945), CBD type II (n\u2009=\u200918), PSP type (n\u2009=\u200926), and frontotemporal dementia type (n\u2009=\u20094). The AD metabolic pattern showed high specificity for amyloid\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      positivity (98.5%) and for combined AD pathology (amyloid\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      plus tau, 98.6%), with correspondingly lower sensitivity (54.2% and 72.2%).\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET patterns further showed high specificity for the PSP tau profile (96.2%) and high sensitivity for the CBD tau profile (97.7%). On spatial analysis, amyloid\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      deposition significantly mediated the regional coupling between tau accumulation and cerebral glucose hypometabolism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET identifies metabolic patterns that correspond to specific proteinopathies underlying CBS with high specificity but requires integration within multimodal biomarker frameworks for comprehensive patient stratification. \u00a9 2026 International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70395","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T01:29:07Z","timestamp":1781486947000},"page":"2432-2443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Brain Metabolic Signatures of Amyloid\u2010\n                    <i>\u03b2<\/i>\n                    and Tau Pathology in Corticobasal Syndrome: A Multimodal Biomarker Study"],"prefix":"10.1002","volume":"41","author":[{"given":"Xin\u2010Yi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0927-0042","authenticated-orcid":false,"given":"Jia\u2010Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET Center Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun\u2010Wang","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6413-5914","authenticated-orcid":false,"given":"Jing\u2010Jie","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET Center Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Min","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Chen","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging Center Chang Gung Memorial Hospital, Chang Gung University  Taoyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8856-7217","authenticated-orcid":false,"given":"Chuan\u2010Tao","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET Center Huashan Hospital, Fudan University  Shanghai China"},{"name":"Human Phenome Institute Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2748-395X","authenticated-orcid":false,"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7688-1631","authenticated-orcid":false,"given":"Feng\u2010Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2019.10.014"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207397"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70662"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01455-x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30489-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.03.012"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007038"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28373"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2022.04.015"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-8815-x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0470-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.70070"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0342-8"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28624"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201389"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29338"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcae075"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70018"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827f0fd1"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24311"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06166-w"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29581"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-016-9322-9"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116189"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-023-09571-7"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-006-0127-z"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28672"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-022-06104-0"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43657-022-00079-6"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000213376"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.02.013"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43657-022-00068-9"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2018180160"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-328586"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000338536.31388.f0"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-025-07552-0"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12143"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa068"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20707"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2025.1734"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00702-6"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28941-1"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70823"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccb.2025.100404"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25968"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu256"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052740"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy146"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.080390"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.70395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.70395","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.70395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:25:10Z","timestamp":1791789910000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.70395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,14]]},"references-count":51,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/mds.70395"],"URL":"https:\/\/doi.org\/10.1002\/mds.70395","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,14]]},"assertion":[{"value":"2026-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}