{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:41:02Z","timestamp":1791841262930,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["09202766"],"award-info":[{"award-number":["09202766"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To conduct a case\u2013control study to investigate melanopsin\u2010mediated post\u2010illumination pupillary response (PIPR) in patients with Parkinson's disease (PD), video\u2010polysomnography\u2010confirmed isolated\/idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD), and age\u2010matched healthy controls (HC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PIPR was measured at 6\u2009s after light offset (PIPR\u20106s). Net PIPR\u20106s was calculated by subtracting the red\u2010light response from the blue\u2010light response. Participants also underwent 1\u2010week actigraphy, overnight urinary 6\u2010sulfatoxymelatonin assessment, and cognitive testing using the Hong Kong Montreal Cognitive Assessment (HK\u2010MoCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We recruited 135 participants (mean age 64.4\u2009\u00b1\u20095.7\u2009years; 56% male), with 45 in each group. Net PIPR\u20106s was 23.8\u2009\u00b1\u20099.4% in HC, 18.6\u2009\u00b1\u200910.8% in iRBD, and 13.3\u2009\u00b1\u20099.6% in PD (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001; HC\u2009&gt;\u2009iRBD &gt; PD). Net PIPR\u20106s was positively associated with circadian rest\u2013activity rhythm amplitude, mesor, and HK\u2010MoCA score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Attenuated PIPR may reflect early dysfunction in melanopsin\u2010mediated phototransduction in the prodromal stage of synucleinopathy. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70412","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:53:38Z","timestamp":1782802418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Melanopsin\u2010Mediated Post\u2010Illumination Pupillary Response in Idiopathic Rapid Eye Movement (\n                    <scp>REM)<\/scp>\n                    Sleep Behavior Disorder and Parkinson's Disease"],"prefix":"10.1002","author":[{"given":"Joey W.Y.","family":"Chan","sequence":"first","affiliation":[{"name":"Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Huang","sequence":"additional","affiliation":[{"name":"Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine The Chinese University of 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