{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:46:45Z","timestamp":1792597605809,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although not confirmed, some studies have suggested that elevated homocysteine levels are common in patients with Huntington's disease (HD). Its clinical relevance remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to assess vitamin B and homocysteine levels in HD patients and explore the relationships among hyperhomocysteinemia, vitamin B deficiency, and motor symptom progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this monocentric case\u2013control study, 77 HD patients were prospectively included between January 2020 and June 2023 at Nancy University Hospital. As controls, biological data were obtained retrospectively from 87 individuals referred to the Metabolic Medicine Department between January 2017 and February 2025. HD patients underwent clinical (Unified Huntington Disease Rating Scale\u2010Motor) and biochemical (vitamin B and homocysteine levels) evaluations. Fisher's exact test, Wilcoxon test, or Student's t\u2010test were used, with\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05 considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HD patients\u2014both symptomatic and premanifest\u2014had significantly higher homocysteine levels than did controls. Hyperhomocysteinemia was found in 36 patients (\u224848%) and was associated with faster motor progression (\n                      <jats:italic>P\u2009&lt;\u20090.001<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Hyperhomocysteinemia appears to be frequent in HD patients and may represent a risk factor contributing to phenotypic variability. These findings support a potential link between altered one\u2010carbon metabolism and HD. Further longitudinal and mechanistic studies are needed to clarify the clinical and pathophysiological relevance of homocysteine metabolism in HD and to determine whether targeting hyperhomocysteinemia could have therapeutic implications. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70413","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:06:36Z","timestamp":1782957996000},"page":"2712-2722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyperhomocysteinemia and Vitamin B Deficiency as Potential Aggravating Factors in Huntington's Disease: A Prospective Monocentric Study"],"prefix":"10.1002","volume":"41","author":[{"given":"Salom\u00e9","family":"Puisieux","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital of Nancy  Nancy France"},{"name":"INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy University of Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Pouri\u00e9","sequence":"additional","affiliation":[{"name":"INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy University of Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6799-0438","authenticated-orcid":false,"given":"C\u00e9line","family":"Bonnet","sequence":"additional","affiliation":[{"name":"INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy University of Lorraine  Nancy France"},{"name":"Laboratory Genetics University Hospital of Nancy  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Hopes","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of Nancy  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol\u00e8ne","family":"Frismand","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of Nancy  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Bronner","sequence":"additional","affiliation":[{"name":"INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy University of Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Roth","sequence":"additional","affiliation":[{"name":"INSERM UMR_S 1256, Nutrition, Genetics, and Environmental 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