{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:47:09Z","timestamp":1792597629012,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Magnetic resonance imaging (MRI)\u2010guided focused ultrasound (MRgFUS) thalamotomy provides durable tremor control for most patients with essential tremor (ET) and tremor\u2010dominant Parkinson's disease (TdPD), but tremor can recur.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the safety, efficacy, and lesion characteristics of repeat MRgFUS thalamotomy for tremor recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed patients undergoing repeat ipsilateral MRgFUS thalamotomy. Clinical Rating Scale for Tremor\u2010Part A (CRST\u2010A) assessed tremor severity preoperatively and 1\u2009day, 1\u2009week, 1\u2009month, 3\u2009months, and 1\u2009year after retreatment. Outcomes, side effects, lesion volumes and locations, and treatment parameters were compared with initial procedures and an institutional one\u2010time MRgFUS cohort (n\u2009=\u2009535).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty patients (26 ET, 4 TdPD) underwent repeat thalamotomy with \u22653\u2009months follow\u2010up. Mean CRST\u2010A improved from 5.37 preoperatively to 0.27 at day 1 (94.9% improvement), 2.00 (64.4%) at 3\u2009months, and 2.50 (38.8%) at 1\u2009year (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2264\u20090.003 vs. baseline). Tremor recurred at similar rates after initial and repeat treatments. Repeat lesions were larger (526.3 vs. 414.1\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      ,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.025) and shifted anteriorly (+1.2\u2009mm,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003). Initial lesion volume in retreatment patients was similar to the one\u2010time cohort. Compared with initial treatments, patients more often experienced any side effect at 1\u2009month (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.023) and had more side effects at 1\u2009month (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 3\u2009months (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.014) after repeat treatment. Patient satisfaction was high and 85% of patients would choose retreatment again.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Repeat ipsilateral MRgFUS thalamotomy restored tremor control after recurrence and achieved high patient satisfaction, despite increased side effects after repeat treatment and similar tremor progression rates after initial and repeat procedures. \u00a9 2026 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70416","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:46:24Z","timestamp":1783665984000},"page":"2668-2676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Repeat Ipsilateral Focused Ultrasound Thalamotomy after Tremor Recurrence: Safety, Efficacy, and Lesion Analysis"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9847-1262","authenticated-orcid":false,"given":"Adam C.","family":"Glaser","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Mass General Brigham Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Neurosurgery Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2832-4002","authenticated-orcid":false,"given":"Melissa M.J.","family":"Chua","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mass General Brigham Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Neurosurgery Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercy","family":"Mazurek","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mass General Brigham Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garance","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Neurology Mass General Brigham  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahyar","family":"Heydarpour","sequence":"additional","affiliation":[{"name":"Department of Medicine, Channing Division of Network Medicine Brigham &amp; Women's Hospital\/Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"McDannold","sequence":"additional","affiliation":[{"name":"Department of Radiology Mass General Brigham  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Horn","sequence":"additional","affiliation":[{"name":"Department of Neurology Mass General Brigham  Boston Massachusetts USA"},{"name":"Institute for Network Stimulation, Department of Stereotactic and Functional Neurosurgery University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Rolston","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mass General Brigham Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Rees","family":"Cosgrove","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mass General Brigham Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300962"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600159"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.3098"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2016311"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/2022.6.JNS212483"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2202721"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2019.00076"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28716"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.2295"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.1220"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws026"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008561"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000098890"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.01.281"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29569"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27348"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.10.JNS181721"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opz300"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3171\/2024.7.FOCVID249"},{"key":"e_1_2_10_21_1","first-page":"271","article-title":"Clinical rating scale for tremor","volume":"2","author":"Fahn S","year":"1993","journal-title":"Parkinson's disease and movement disorders"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adp0532"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.871905"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.086579"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22370"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27821"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.70416","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.70416","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.70416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:55:38Z","timestamp":1792594538000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.70416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/mds.70416"],"URL":"https:\/\/doi.org\/10.1002\/mds.70416","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]},"assertion":[{"value":"2026-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}