{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:46:41Z","timestamp":1782960401494,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD)\u2010related pathology may co\u2010occur in progressive supranuclear palsy (PSP), although its clinical and prognostic impact is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess whether cerebrospinal fluid (CSF) AD biomarker profiles at diagnosis predict severity and survival in PSP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CSF amyloid\u2010\u03b242 (A\u03b242), total and phosphorylated tau (t\u2010tau, p\u2010tau) levels from 85 newly\u2010diagnosed PSP patients and 59 controls were assessed by the amyloid\/tau\/neurodegeneration (AT[N]) framework, and the p\u2010tau\/A\u03b242 ratio (AD+ if \u22650.08), and implemented in a survival analysis through Kaplan\u2013Meier, Cox regression, and LASSO\u2010Cox modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AD CSF signature was identified in 5.9% and 18.8% of PSP patients, according to AT(N) and ratio, respectively. It was unrelated to phenotype or severity but strongly predicted survival, with AD+ patients showing markedly shorter survival. The p\u2010tau\/A\u03b242 ratio was the strongest independent predictor of mortality, together with phenotype and smoking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AD\u2010related CSF signature defines a biological PSP subgroup with shortened survival. The p\u2010tau\/A\u03b242 ratio offers a pragmatic prognostic tool for patient stratification. \u00a9 2026 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70418","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:32:14Z","timestamp":1782959534000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alzheimer's Disease Cerebrospinal Fluid Biomarkers Predict Survival in Progressive Supranuclear Palsy"],"prefix":"10.1002","author":[{"given":"Davide","family":"Mascioli","sequence":"first","affiliation":[{"name":"Unit of Neurology, Department of Systems Medicine University of Rome Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Mancini","sequence":"additional","affiliation":[{"name":"Unit of Neurology, Department of Systems Medicine University of Rome Tor 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