{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:59:06Z","timestamp":1785466746329,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["009421\/17483"],"award-info":[{"award-number":["009421\/17483"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>DNAJC13<\/jats:italic>\n                      was initially linked to autosomal dominant (AD) Parkinson's disease (PD) in a European Mennonite family carrying the p.N855S variant. However, imperfect segregation and conflicting reports of pathogenicity raised uncertainty of the role of\n                      <jats:italic>DNAJC13<\/jats:italic>\n                      in the disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The objective for this study was to explore the association between common and rare variants in\n                      <jats:italic>DNAJC13<\/jats:italic>\n                      and PD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We leveraged the largest available PD genetics data from the Accelerating Medicines Partnership\u2014Parkinson Disease and the diverse ancestry available through the Global Parkinson's Genetics Program (GP2), consisting of 2471 patients and 3098 control subjects and 44,186 patients and 27,066 control subjects, respectively, to perform burden tests and association tests for rare and common variants, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Burden analysis showed no association between rare variants in\n                      <jats:italic>DNAJC13<\/jats:italic>\n                      and PD. However, association analysis within common nonsynonymous variants nominated five variants within\n                      <jats:italic>DNAJC13.<\/jats:italic>\n                      Nevertheless, these associations require further investigation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our analysis did not find further evidence supporting\n                      <jats:italic>DNAJC13<\/jats:italic>\n                      involvement in PD. However, studies of even larger cohorts and AD\u2010PD families may bring definite answers about the role of\n                      <jats:italic>DNAJC13<\/jats:italic>\n                      in PD. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70429","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:15:56Z","timestamp":1785464156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>\n                      <i>DNAJC13<\/i>\n                    <\/scp>\n                    Variants Show No Robust Association With Parkinson's Disease in a Multiancestry Cohort"],"prefix":"10.1002","author":[{"given":"C\u00e9sar Luis","family":"\u00c1vila","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Medicina Molecular y Celular Aplicada (IMMCA) CONICET|UNT|SIPROSA  San Miguel de Tucum\u00e1n Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Isayan","sequence":"additional","affiliation":[{"name":"Somnus Neurology Clinic  Yerevan Armenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Mecheri","sequence":"additional","affiliation":[{"name":"Department of Neurology Dr Benbadis University Hospital  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Saffie\u2010Awad","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Santa Mar\u00eda  Santiago Chile"},{"name":"Department of Specialties, Faculty of Medicine University of Concepci\u00f3n  Concepci\u00f3n Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Milagros","family":"Leila","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Medicina Molecular y Celular Aplicada (IMMCA) CONICET|UNT|SIPROSA  San Miguel de Tucum\u00e1n Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel A.","family":"Screven","sequence":"additional","affiliation":[{"name":"Data Tecnica, LLC  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hampton","family":"Leonard","sequence":"additional","affiliation":[{"name":"Data Tecnica, LLC  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7412-7440","authenticated-orcid":false,"given":"Maria Teresa","family":"Peri\u00f1an","sequence":"additional","affiliation":[{"name":"Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London  London United Kingdom"},{"name":"Unidad de Trastornos del Movimiento, Servicio de Neurolog\u00eda y Neurofisiolog\u00eda Cl\u00ednica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Roc\u00edo\/Consejo Superior de Investigaciones Cient\u00edficas\/Universidad de Sevilla  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Yeboah","sequence":"additional","affiliation":[{"name":"Data Tecnica, LLC  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Levine","sequence":"additional","affiliation":[{"name":"Data Tecnica, LLC  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7978-1051","authenticated-orcid":false,"given":"Mary B.","family":"Makarious","sequence":"additional","affiliation":[{"name":"Data Tecnica, LLC  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Global Parkinson's Genetics Program 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