{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:00:07Z","timestamp":1790024407242,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K00NS124190"],"award-info":[{"award-number":["K00NS124190"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["F32NS128392"],"award-info":[{"award-number":["F32NS128392"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RF1NS131165"],"award-info":[{"award-number":["RF1NS131165"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R61NS126026"],"award-info":[{"award-number":["R61NS126026"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS120663"],"award-info":[{"award-number":["R01NS120663"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013301","name":"Parkinson's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013301","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pain is a common and debilitating non\u2010motor symptom of Parkinson's disease (PD), yet its underlying neural mechanisms remain poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim was to test whether neuropeptide Y Y1 receptor (Npy1r)\u2010expressing parabrachial neuronsdrive PD\u2010associated pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a unilateral 6 hydroxydopamine (6\u2010OHDA) mouse model, pain\u2010related behaviors, neuronal activation, and intrinsic excitability of parabrachial nucleus (PBN) neurons were assessed using behavioral assays, fluorescence in situ hybridization, and ex vivo whole\u2010cell patch\u2010clamp electrophysiology. Cell type\u2010specific chemogenetic inhibition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following 6\u2010OHDA injection, mice developed robust multimodal hypersensitivity accompanied by increased recruitment of\n                      <jats:italic>Npy1r<\/jats:italic>\n                      \u2010expressing PBN neurons. Chemogenetic silencing of\n                      <jats:italic>Npy1r<\/jats:italic>\n                      \u2010expressing PBN neurons abolished PD\u2010associated hypersensitivity, whereas activation induced pain\u2010like behaviors in na\u00efve mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Npy1r<\/jats:italic>\n                      \u2010expressing PBNs are a discrete supraspinal population that drives pain in a preclinical model of PD. \u00a9 2026 International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70442","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:26:48Z","timestamp":1785472008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Parabrachial\n                    <scp>\n                      <i>Npy1r<\/i>\n                    <\/scp>\n                    \u2010Expressing Neurons Drive Pain in a Mouse Model of Parkinson's Disease"],"prefix":"10.1002","author":[{"given":"Tyler S.","family":"Nelson","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics McKnight Brain Institute, and Center for Advanced Pain Therapeutics and Research (CAPToR), College of Medicine, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather N.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics McKnight 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