{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:48:49Z","timestamp":1791791329424,"version":"4.3.4"},"reference-count":65,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102026\u201025498013"],"award-info":[{"award-number":["RS\u20102026\u201025498013"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Concurrent Alzheimer's disease pathology is increasingly recognized as a poor prognostic factor in Parkinson's disease (PD), yet reliable clinical indicators for early identification of AD copathology remain poorly established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate baseline motor and nonmotor symptom profiles associated with amyloid\u2010\u03b2 (A\u03b2) copathology in newly diagnosed PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among patients with PD who underwent A\u03b2 imaging, we retrospectively identified 152 patients who completed the Cross\u2010Cultural Smell Identification Test (CC\u2010SIT), autonomic function tests, neuropsychological assessment, and Neuropsychiatric Inventory Questionnaire (NPI\u2010Q) at drug\u2010naive state. Predictors of A\u03b2 positivity were identified using stepwise multivariable logistic regression and validated with Random Forest classifiers employing Boruta feature selection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with A\u03b2\u2010negative counterparts (n\u2009=\u200993), A\u03b2\u2010positive (A\u03b2\u2009+\u2009PD, n\u2009=\u200959) patients demonstrated greater olfactory dysfunction (CC\u2010SIT,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002), dysautonomia (Composite Autonomic Severity Scale [CASS],\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and mood disturbance (NPI\u2010Q\u2010mood,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and higher prevalence of probable rapid eye movement sleep behavior disorder (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.009) and neurogenic orthostatic hypotension (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.006). A\u03b2\u2009+\u2009PD patients showed greater motor disability (Unified Parkinson's Disease Rating Scale Part III [UPDRS\u2010III],\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) despite comparable striatal dopamine transporter uptake. Logistic regression identified lower CC\u2010SIT scores (odds ratio [OR]\u2009=\u20090.821, 95% confidence interval [CI\n                      <jats:sub>95%<\/jats:sub>\n                      ]: 0.703\u20130.959), higher CASS scores (OR\u2009=\u20091.380, CI\n                      <jats:sub>95%<\/jats:sub>\n                      : 1.144\u20131.666), higher NPI\u2010Q\u2010mood scores (OR\u2009=\u20091.057, CI\n                      <jats:sub>95%<\/jats:sub>\n                      : 1.005\u20131.111), higher UPDRS\u2010III (OR\u2009=\u20091.080, CI\n                      <jats:sub>95%<\/jats:sub>\n                      : 1.030\u20131.132), and APOE \u03b54 carrier status (OR\u2009=\u20093.643, CI\n                      <jats:sub>95%<\/jats:sub>\n                      : 1.479\u20138.969) as independent predictors of A\u03b2 positivity, which were also confirmed as important variables by Boruta feature selection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our findings suggest that greater motor and nonmotor symptom burden at diagnosis, characterized by olfactory\/autonomic dysfunction, mood disturbance, and motor deficits disproportionate to dopaminergic denervation, was associated with A\u03b2 positivity in PD. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70446","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:34:21Z","timestamp":1785292461000},"page":"2299-2309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Greater Motor and Nonmotor Burden at Diagnosis Is Associated With Amyloid Copathology in Parkinson's Disease"],"prefix":"10.1002","volume":"41","author":[{"given":"Han Kyu","family":"Na","sequence":"first","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2641-9592","authenticated-orcid":false,"given":"Yeeun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology Inje University Sanggye Paik Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Wook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Physiology Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5082-1075","authenticated-orcid":false,"given":"Jung 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