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and evaluate its association with clinical progression in PSP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010six patients with PSP (18 Richardson's syndrome [PSP\u2010RS], 8 non\u2010RS) and 10 age\u2010 and sex\u2010matched healthy controls (HCs) underwent florzolotau PET, magnetic resonance imaging, and clinical assessments at baseline and after 1\u2009year. Regional standardized uptake value ratios (SUVRs) were extracted across 57 regions of interest. Partial least squares (PLS) multivariate analyses revealed regions with elevated baseline SUVR and longitudinal increase (\u0394SUVR) in PSP relative to HCs, alongside regions where \u0394SUVR was associated with changes in PSP Rating Scale scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, tau deposition was most prominent in the globus pallidus (GP) and midbrain in patients with PSP. Longitudinal tau increases were observed in the GP, frontoparietal cortex, and cerebellar white matter, and minimal progression was observed in the midbrain. GP tau accumulation exhibited the strongest association with clinical progression in the PLS model among PSP\u2010RS and a univariate correlation (Spearman's\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.688,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study provides in vivo evidence of the spatiotemporal progression of tau pathology in PSP. In the GP, tau accumulation emerges early and continues to increase with clinical deterioration. These findings support the utility of florzolotau PET for monitoring disease progression and as a biological outcome measure in tau\u2010targeted therapeutic trials. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70468","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:08:44Z","timestamp":1788534524000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatiotemporal Tau Accumulation and its Clinical Impact on Progressive Supranuclear Palsy: Longitudinal Florzolotau (\n                    <scp>18F<\/scp>\n                    ) Positron Emission\n                    <scp>T<\/scp>\n                    omography"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6877-6898","authenticated-orcid":false,"given":"Yoshikazu","family":"Chishiki","sequence":"first","affiliation":[{"name":"Advanced Neuroimaging Center, Institute for Quantum Medial Science National Institutes for Quantum Science and Technology (QST)  Chiba Japan"},{"name":"Department of Neurology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Tagai","sequence":"additional","affiliation":[{"name":"Advanced Neuroimaging Center, Institute for Quantum Medial Science National Institutes for Quantum Science and Technology (QST)  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7584-1005","authenticated-orcid":false,"given":"Yuko","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Advanced Neuroimaging Center, Institute for Quantum Medial Science 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