{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T07:14:10Z","timestamp":1788333250592,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Mutations in the glucocerebrosidase 1 (\n                      <jats:italic>GBA1<\/jats:italic>\n                      ) and leucine\u2010rich repeat kinase 2 (\n                      <jats:italic>LRRK2<\/jats:italic>\n                      ) genes are associated with Parkinson's disease (PD) phenotype.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To asses the contribution of genetic status to long\u2010term survival of patients with PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 2039 PD patients with Ashkenazi ancestry were genotyped for mutations in the\n                      <jats:italic>GBA1<\/jats:italic>\n                      and\n                      <jats:italic>LRRK2<\/jats:italic>\n                      genes between 2005 and 2025 at Tel\u2010Aviv Medical Center. National death registries were studied to identify date of death. The primary endpoint was defined as overall survival. Regression analysis was performed to assess the risk for each group. Separate analysis comparing early\u2010onset PD (EOPD, age of onset &lt;50) to late\u2010onset PD (LOPD) was also conducted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mortality hazard ratios (HRs) were increased for\n                      <jats:italic>GBA1<\/jats:italic>\n                      \u2010PD (1.52; 95% confidence interval [CI]: 1.27\u20131.81) and reduced for\n                      <jats:italic>LRRK2<\/jats:italic>\n                      \u2010PD (0.76; 95% CI: 0.59\u20130.96) compared to idiopathic PD (iPD). Median survival for all groups was lower than expected, ranging from 18 to 20\u2009years from onset. Women were associated with lower mortality HR\u2009=\u20090.69 (95% CI: 0.60\u20130.79). EOPD patients had increased overall disease duration compared to LOPD, with lower survival and age at death (67.8\u2009\u00b1\u20099.3 vs. 80.2\u2009\u00b1\u20097.3), consistent across genetic subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      PD is associated with reduced longevity compared to population norms.\n                      <jats:italic>LRRK2<\/jats:italic>\n                      \u2010PD has reduced mortality, and\n                      <jats:italic>GBA1<\/jats:italic>\n                      \u2010PD has increased mortality compared to iPD. EOPD is associated with longer disease duration and lower overall life expectancy compared to patients with LOPD. These findings can assist in discussing prognosis with patients and demonstrate the need for research directed at these subgroups to identify factors and interventions to help personalize patient care. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70494","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:27:55Z","timestamp":1788330475000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of\n                    <scp>\n                      <i>LRRK2<\/i>\n                    <\/scp>\n                    and\n                    <scp>\n                      <i>GBA1<\/i>\n                    <\/scp>\n                    Mutations on Survival in Early\u2010 and Late\u2010Onset Parkinson's Disease"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4902-7240","authenticated-orcid":false,"given":"Raz","family":"Rubin","sequence":"first","affiliation":[{"name":"Gray Faculty of Medical &amp; 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