{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T08:11:40Z","timestamp":1788595900434,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS060722"],"award-info":[{"award-number":["NS060722"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS082151"],"award-info":[{"award-number":["NS082151"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RR033184"],"award-info":[{"award-number":["RR033184"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["TR000127"],"award-info":[{"award-number":["TR000127"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["TR002014"],"award-info":[{"award-number":["TR002014"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004897","name":"Pennsylvania Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["18078"],"award-info":[{"award-number":["18078"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Progression of substantia nigra pars compacta\u00a0(SNc) iron content in early\u2010stage Parkinson's patients (PD) is poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine if nigral iron measured by quantitative susceptibility mapping (QSM) with zero\u2010referencing\u00a0\u00a0 \u00a0can track disease progression in early\u2010stage PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010four early\u2010stage PD patients and 35 matched controls were recruited. Iron content in the SNc and related regions were obtained using QSM\u00a0with zero\u2010referencing at both baseline and 1\u2010year follow\u2010up, along with clinical metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of seven clinic metrics and five regional iron measures, only Movement Disorder Society\u2010Unified Parkinson's Disease Rating Scale\u2010Part II (MDS\u2010UPDRS\u2010II) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.046) and SNc iron (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0025 for cerebrospinal fluid zero\u2010referencing;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.014 for whole\u2010brain zero\u2010referencing) showed significant changes in PD subjects in the 1\u2010year epoch. The changes in SNc iron were also correlated with changes in MDS\u2010UPDRS\u2010II (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nigral iron content measured by zero\u2010referencing QSM can be used to track disease progression in early\u2010stage PD over the 1\u2010year epoch. \u00a9 2026 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70497","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T07:32:51Z","timestamp":1788593571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Iron Changes in the Substantia Nigra of Early\u2010Stage Parkinson's 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-9445","authenticated-orcid":false,"given":"Lan","family":"Kong","sequence":"additional","affiliation":[{"name":"School of Public Health Sciences Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1353-2738","authenticated-orcid":false,"given":"Richard B.","family":"Mailman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3583-5502","authenticated-orcid":false,"given":"Xuemei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Virginia  Charlottesville Virginia 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