{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:58:13Z","timestamp":1790665093653,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/07559\u20103"],"award-info":[{"award-number":["2013\/07559\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>SCA27B is a recently described ataxia, the precise anatomical basis of which remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The goal was to characterize the structural brain and spinal cord magnetic resonance imaging (MRI) signature of spinocerebellar ataxia 27B (SCA27B) using multimodal quantitative imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross\u2010sectional, multisite study, 28 genetically confirmed SCA27B patients underwent standardized 3\u2009T brain and cervical spinal cord MRI. A group of age\u2010 and sex\u2010matched healthy controls was recruited at participating centers using harmonized acquisition protocols. Cerebral and cerebellar volumetry were performed using FastSurfer and CerebNet, respectively. Diffusion tensor imaging was used to assess microstructural integrity in supratentorial white matter. Spinal cord gray and white matter areas were quantified at the cervical level using the SCT toolbox. Between\u2010group comparisons were conducted using general linear models adjusted for age, sex, and site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean age and Scale for the Assessment and Rating of Ataxia score of the SCA27B cohort were 68.7\u2009\u00b1\u200913.3\u2009years and 10.5\u2009\u00b1\u20095.8 points. Compared with healthy controls, SCA27B patients exhibited significant volumetric reduction of the cerebellar vermis (lobules I to IV and vermis VIII). Diffusion analyses revealed widespread fractional anisotropy reduction in subcortical cerebral white matter, consistent with microstructural disruption. At the cervical spinal cord level, patients demonstrated significant gray matter area reduction, whereas white matter area was comparatively preserved. The combined pattern of vermian atrophy, supratentorial white matter diffusivity abnormalities, and spinal cord gray matter loss delineated a distinct structural signature of SCA27B.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      SCA27B is associated with a structural phenotype extending beyond the cerebellum, involving subcortical white matter microstructure and spinal cord gray matter. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70532","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:14:53Z","timestamp":1790662493000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural Brain and Spinal Cord Signature of Spinocerebellar Ataxia\n                    <scp>27B<\/scp>\n                    : A Multisite\n                    <scp>MRI<\/scp>\n                    \u2010Based Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2504-1100","authenticated-orcid":false,"given":"Nadson Bruno Serra","family":"Santos","sequence":"first","affiliation":[{"name":"Department of Neurology School of Medical Sciences\u2014University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0790-8870","authenticated-orcid":false,"given":"Camila 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Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1394-3561","authenticated-orcid":false,"given":"Bernard","family":"Brais","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery Montreal Neurological Hospital and Institute, McGill University  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4207-5065","authenticated-orcid":false,"given":"Roberta La","family":"Piana","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery Montreal Neurological Hospital and Institute, McGill University  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemimah","family":"Harding","sequence":"additional","affiliation":[{"name":"Human NeuroMovement Research Group Bionics Institue\/University of 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