{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:51:44Z","timestamp":1791352304402,"version":"4.3.1"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson's disease (PD) is frequently accompanied by neuropsychiatric symptoms (NPS), including cognitive impairment, which often emerge early and co\u2010occur. Their long\u2010term evolution remains incompletely characterized, particularly in biomarker\u2010positive cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim was to examine the evolution of NPS in biomarker\u2010positive PD over the first decade following diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Parkinson's Precision Medicine Initiative data were used to evaluate nine NPS in dual biomarker\u2010positive PD (positive cerebrospinal fluid \u237a\u2010synuclein seed amplification assay and abnormal dopamine transporter single\u2010photon emission computed tomography; n\u2009=\u2009846) and healthy controls (HCs; n\u2009=\u2009282). Analyses included generalized estimating equations (GEEs), principal components analysis (PCA), and cluster analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In PD, absolute prevalence of eight NPS increased over 10\u2009years (6.6%\u201323.5%), while anxiety declined slightly. Prevalence in HCs remained low and stable. GEE models demonstrated increasing odds of all NPS in PD except anxiety, with notable increases in psychosis (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.17\u20131.25) and apathy (OR,\u20091.17; 95% CI, 1.13\u20131.22). PD participants had higher rates of depression, psychosis, apathy, rapid eye movement sleep behavior disorder, excessive daytime sleepiness, impulse control disorders, and impaired cognition than HCs over time. Mean NPS count increased in PD (1.39 to 2.39), but remained stable in HCs (0.60 to 0.58). PCA identified a stable affective domain, a perceptual domain that included cognitive and sleep symptoms, and a time\u2010varying motivational\u2010behavioral domain. Cluster analysis at diagnosis identified low\u2010 and high\u2010burden NPS subgroups that remained applicable at 5\u2010 and 10\u2010year timepoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      NPS increase in prevalence and co\u2010occurrence over 10\u2009years in biomarker\u2010positive, sporadic PD. Time\u2010varying symptom groupings and persistent low\u2010 and high\u2010NPS burden phenotypes further highlight the progressive and heterogeneous nature of NPS evolution in PD. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70557","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:48:07Z","timestamp":1791352087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuropsychiatric and Cognitive Symptom Evolution over the First Decade of Biomarker\u2010Positive, Sporadic Parkinson's Disease"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0854-5611","authenticated-orcid":false,"given":"Izabelle","family":"Schoen","sequence":"first","affiliation":[{"name":"Department of Psychiatry Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon X.","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0933-1039","authenticated-orcid":false,"given":"Chelsea","family":"Caspell\u2010Garcia","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Mamikonyan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Stark","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila","family":"Dahodwala","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Siderowf","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseanne","family":"Dobkin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Rutgers Robert Wood Johnson Medical School  New Brunswick NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4056-0742","authenticated-orcid":false,"given":"Michele K.","family":"York","sequence":"additional","affiliation":[{"name":"Department of Neurology Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-7168","authenticated-orcid":false,"given":"Daniel","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"},{"name":"Department of Neurology Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"},{"name":"Philadelphia Veterans Affairs Medical Center  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson's disease","volume":"30","author":"Postuma RB","year":"2015","journal-title":"Mov 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