{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:49:32Z","timestamp":1791625772175,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG064010"],"award-info":[{"award-number":["R01AG064010"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The cerebellum is increasingly recognized as a key contributor to cognitive reserve and network organization in Parkinson's disease (PD). However, the relationship of cerebello\u2010cortical and cerebello\u2010basal ganglia connectivity with cognitive status and nigrostriatal integrity remains incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Resting\u2010state functional magnetic resonance imaging (fMRI) data from 172 participants with PD in the Parkinson's Precision Medicine Initiative were analyzed. Cerebello\u2010basal ganglia and cerebello\u2010cortical connectivity were investigated using region of interest (ROI)\u2010to\u2010ROI and seed\u2010to\u2010voxel approaches. Cerebellar connectivity was examined in relation to cognitive status, age, disease duration, motor severity, dopaminergic medication exposure, and contralateral putaminal striatal binding ratio (SBR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PD participants demonstrated robust positive cerebello\u2010basal ganglia connectivity, particularly between lobule VI\/vermis VI and the pallidum. Greater age was associated with widespread reductions in cerebello\u2010basal ganglia coupling. Longer disease duration was associated with stronger connectivity within cerebellar and basal ganglia circuits, and among cognitively unimpaired participants, stronger lobule V connectivity with temporal regions. After adjustment for contralateral putaminal SBR, cognitively unimpaired participants generally demonstrated greater connectivity between left cerebellar regions and frontal networks, whereas cognitively impaired participants showed greater connectivity from posterior cerebellar and vermal regions, including regions implicated in cognitive processing, to temporal, parahippocampal, occipital, parietal, and somatosensory regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Cerebellar functional connectivity in PD shows region\u2010specific differences across cognitive status rather than uniform network loss with cognitive impairment. These findings support further investigation of cerebellar functional connectivity as a candidate biomarker of cognitive resilience and network adaptation in PD. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70564","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:07:11Z","timestamp":1791623231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebellar Network Organization in Parkinson's Disease: Functional Connectivity across Motor and Cognitive Circuits"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-974X","authenticated-orcid":false,"given":"Chi\u2010Ying R.","family":"Lin","sequence":"first","affiliation":[{"name":"Alzheimer's Disease and Memory Disorders Center, Department of Neurology Baylor College of Medicine  Houston Texas USA"},{"name":"Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0825-1387","authenticated-orcid":false,"given":"Thamires N.C.","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3377-2827","authenticated-orcid":false,"given":"Shayla S.","family":"Yonce","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease and Memory Disorders Center, Department of Neurology Baylor College of Medicine  Houston Texas 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