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ICDs and CBs were assessed with the full QUIP (Questionnaire for Impulsive\u2010Compulsive Disorders in Parkinson\u2019s Disease) in Seville and the short form (QUIP\u2010S) in PPMI. Dopaminergic exposure was quantified as levodopa\u2010 and dopamine agonist\u2010equivalent daily doses. A candidate\u2010variant panel selected through systematic review was evaluated using covariate\u2010adjusted case\u2013control analyses with empirical\n                      <jats:italic>P<\/jats:italic>\n                      \u2010values from 5000 permutations, followed by random\u2010effects meta\u2010analysis, exploratory genotype\u2010by\u2010treatment analyses, and in silico functional annotation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      rs702859, a synonymous\n                      <jats:italic>KCNJ6<\/jats:italic>\n                      variant, was associated with CBs in Seville (odds ratio [OR] 1.46; 95% confidence interval [CI] 1.02\u20132.09) and with ICDs in PPMI (OR 1.56; 95% CI 1.11\u20132.19). Meta\u2010analysis supported an association with ICDs (pooled OR 1.36; 95% CI 1.03\u20131.80). Exploratory analyses showed nominal interactions between rs702859 and dopamine agonist dose in Seville that were not reproduced in PPMI. rs702859 was in strong linkage disequilibrium with rs146589674, a\n                      <jats:italic>KCNJ6<\/jats:italic>\n                      3\u2032 untranslated region variant; expression, chromatin accessibility, and methylation quantitative trait loci (QTL) data linked risk alleles to reduced\n                      <jats:italic>KCNJ6<\/jats:italic>\n                      expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>KCNJ6<\/jats:italic>\n                      rs702859 showed convergent variant\u2010level associations across related impulsive\u2013compulsive phenotypes in two independent cohorts, supporting further investigation of\n                      <jats:italic>KCNJ6<\/jats:italic>\n                      \u2010related pathways. Independent functional and clinical validation is required. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70586","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:10:49Z","timestamp":1792649449000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross\u2010Cohort Evidence Links\n                    <scp>\n                      <i>KCNJ6<\/i>\n                    <\/scp>\n                    rs702859 to Impulsive\u2013Compulsive Phenotypes in Parkinson's Disease"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0207-9026","authenticated-orcid":false,"given":"Sergio","family":"Garc\u00eda\u2010D\u00edaz","sequence":"first","affiliation":[{"name":"Unidad de Trastornos del Movimiento, Servicio de Neurolog\u00eda Instituto de Biomedicina de Sevilla, IBiS\/Hospital Universitario Virgen Del Roc\u00edo\/Universidad de Sevilla  Sevilla Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Departamento de Medicina, Facultad de Medicina Universidad de Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1392-8775","authenticated-orcid":false,"given":"Juan Francisco","family":"Mart\u00edn\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Unidad de Trastornos del Movimiento, Servicio de Neurolog\u00eda Instituto de Biomedicina de Sevilla, IBiS\/Hospital Universitario Virgen Del Roc\u00edo\/Universidad de Sevilla  Sevilla Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Departamento de Psicolog\u00eda, Facultad de Psicolog\u00eda Universidad de Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8818-1824","authenticated-orcid":false,"given":"Laura","family":"Mu\u00f1oz\u2010Delgado","sequence":"additional","affiliation":[{"name":"Unidad de Trastornos del Movimiento, Servicio de Neurolog\u00eda Instituto de Biomedicina de Sevilla, IBiS\/Hospital Universitario Virgen Del Roc\u00edo\/Universidad de Sevilla  Sevilla Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED) Instituto de Salud Carlos III  Madrid 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