{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:37:45Z","timestamp":1790181465992,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":6494,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twenty\u2010three patients with Gilles de la Tourette's syndromes (GTS) underwent nonivasive investigation of autonomic nervous system (ANS) function, as did 23 age\u2010matched controls. ANS function in GTS patients was no different from that of controls, and patients receiving neuroleptic drugs had the same ANS function as untreated patients. All 23 patients later received clonidine and were retested. The ANS values before administration of clonidine were compared with those while patients were taking clonidine. The only significant change (p &lt;0.01) with clonidine was a reduced resting pulse rate. The combination of clonidine and neuroleptic drugs did not induce significant autonomic changes compared with neuroleptoc therapy alone. These results indicate that the ANS in GTS patients is normal and that the drugs used to abate tics do not produce clinically significant changes in ANS when chronically given. The findings suggest that the pathophysiology and treatment of GTS do not directly involve the nuclei or tracts of autonomic regulation.<\/jats:p>","DOI":"10.1002\/mds.870020203","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T06:56:43Z","timestamp":1104562603000},"page":"99-102","source":"Crossref","is-referenced-by-count":6,"title":["The autonomic nervous system in Gilles de la Tourette's syndrome"],"prefix":"10.1002","volume":"2","author":[{"given":"Christopher G.","family":"Goetz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Shannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Susan","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline M.","family":"Tanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall","family":"Weingarten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Gilles de la Tourette syndrome","author":"Shapiro AK","year":"1978"},{"key":"e_1_2_1_3_2","first-page":"435","article-title":"Tourette syndrome: clinical and psychological aspects of 250 cases","volume":"37","author":"Comings DE","year":"1985","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_4_2","first-page":"19","article-title":"Etude sur une affection nerveuse caracterisee par de 1\u2032incoordination motrice accompagnee d'echolalie et de corprolalie","volume":"9","author":"de la Tourette G. Gilles","year":"1885","journal-title":"Arch Neurol (Paris)"},{"issue":"1","key":"e_1_2_1_5_2","first-page":"238","article-title":"Tics and body temperature: Gilles de la Tourette's observations tested","volume":"35","author":"Shannon KM","year":"1985","journal-title":"Neurology"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.3.343"},{"key":"e_1_2_1_7_2","volume-title":"Goodman and Gillman's The pharmacological basis of therapeutics","author":"Gilman AG","year":"1985"},{"key":"e_1_2_1_8_2","volume-title":"Autonomic failure","author":"Bannister R","year":"1983"},{"key":"e_1_2_1_9_2","volume-title":"Disorders of the autonomic nervous system","author":"Johnson RH","year":"1974"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1981.01780350025002"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.2.4.372"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198000021-00002"},{"key":"e_1_2_1_13_2","first-page":"221","volume-title":"Neuropharmacology: clinical applications","author":"Shearman GT","year":"1982"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.870020203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.870020203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:18:35Z","timestamp":1760959115000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.870020203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1002\/mds.870020203"],"URL":"https:\/\/doi.org\/10.1002\/mds.870020203","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}