{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:58:28Z","timestamp":1790179108703,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":6129,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1988,1]]},"abstract":"Abstract<\/jats:title>\n \n Administration of\n L<\/jats:sc>\n \u2010dopa (\n L<\/jats:sc>\n , 4\u2010dihydroxyphenylalanine) (200mg\/kg p.o.) to rats produced elevated plasma and muscle concentrations of both\n L<\/jats:sc>\n \u2010dopa and 3\u2010O\u2010methyldopa (3\u2010OMD). This effect was potentiated by simultaneous administration of carbidopa (25 mg\/kg p.o.) both\n L<\/jats:sc>\n \u2010dopa and 3\u2010OMD accumulated in muscle after administration of\n L<\/jats:sc>\n \u2010dopa with or without carbidopa. Elevated dopamine levels were detected in both muscle and plasma after treatment with\n L<\/jats:sc>\n \u2010dopa alone. Concurrent administration of carbidopa only diminished dopamine levels in plasma, and the duration of raised dopamine levels in muscle was increased. Carbidopa administration had no effect on the elevated plasma concentrations of 3,4\u2010dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) caused by\n L<\/jats:sc>\n \u2010dopa administration. In muscle, carbidopa treatment tended to prolong the duration of raised metabolite levels. Muscle appears to accumulate\n L<\/jats:sc>\n \u2010dopa at a site where decarboxylation is not totally prevented by concurrent carbidopa administration, and where dopamine is not degraded as actively as in other tissues. The muscle sink for\n L<\/jats:sc>\n \u2010dopa may influence the plasma profile of the amino acid, which has implications for the therapeutic response to\n L<\/jats:sc>\n \u2010dopa in Parkinson's disease.\n <\/jats:p>","DOI":"10.1002\/mds.870030203","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T07:46:48Z","timestamp":1104565608000},"page":"117-125","source":"Crossref","is-referenced-by-count":30,"title":["The effect of carbidopa on plasma and muscle levels of\n L<\/scp>\n \u2010dopa, dopamine, and their metabolites following\n L<\/scp>\n \u2010dopa administration to rats"],"prefix":"10.1002","volume":"3","author":[{"given":"S.","family":"Rose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Jenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. D.","family":"Marsden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"589","article-title":"Tissue distribution of L\u2010dopa: evidence for a reservoir in skeletal muscle","volume":"31","author":"Ordonez LA","year":"1972","journal-title":"Fed Proc"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0022-3565(25)29385-5","article-title":"Effects of L\u2010dopa administration on the concentration of dopa, dopamine and norepinephrine in various rat tissues","volume":"184","author":"Romero JA","year":"1973","journal-title":"J Pharmac Exp Ther"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-0-12-510604-7.50008-6","volume-title":"Mammalian protein metabolsim","author":"Munro HN","year":"1970"},{"key":"e_1_2_1_5_2","first-page":"586","volume-title":"Mammalian protein metabolism","author":"Young VR","year":"1970"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64731-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1975.tb04415.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(75)90248-9"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(78)90340-5"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(73)90266-9"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(78)90033-3"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90622-5"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1177\/014107687907201211","article-title":"Metabolic functions of skeletal muscles of man, mammals, birds and fishes: a review","volume":"32","author":"Spargo E","year":"1979","journal-title":"J Roy Soc Med"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.870030203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.870030203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:57:26Z","timestamp":1760957846000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.870030203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,1]]}},"alternative-id":["10.1002\/mds.870030203"],"URL":"https:\/\/doi.org\/10.1002\/mds.870030203","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,1]]}}}