{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:43:47Z","timestamp":1790754227754,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":5398,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rett syndrome, a progressive neurodegenerative disorder described only in female subjects, is manifested by a wide spectrum of behavioral and motor abnormalities. We studied 32 patients with this disorder, ages 30 months to 28 years old, and characterized their extrapyramidal disturbance. The most common motor abnormalities were stereotyped movements and gait disturbance, seen in all patients. Bruxism, oculogyric crises, parkinsonism, and dystonia were also common, but myoclonus and choreoathetosis were seen only infrequently. The hyperkinetic movement disorders tended to dominate in younger patients, while bradykinetic disorders were more evident in the older patients. This study provides evidence that movement disorders seen in Rett syndrome reflect age\u2010related neurodegenerative changes in the basal ganglia.<\/jats:p>","DOI":"10.1002\/mds.870050303","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T18:48:19Z","timestamp":1104518899000},"page":"195-202","source":"Crossref","is-referenced-by-count":114,"title":["Rett syndrome and associated movement disorders"],"prefix":"10.1002","volume":"5","author":[{"given":"Patricia M.","family":"FitzGerald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Jankovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan K.","family":"Percy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"723","article-title":"Uber ein eigenartiges hirnatrophisches Syndrom bei hyperammonamie im Kindersalter","volume":"116","author":"Rett A","year":"1966","journal-title":"Wien Med Wochenschr"},{"key":"e_1_2_1_3_2","first-page":"305","volume-title":"Handbook of Clinical Neurology","author":"Rett A","year":"1977"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140412"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(85)80048-6"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250506"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230432"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.2.293"},{"key":"e_1_2_1_9_2","first-page":"117","article-title":"Rett syndrome: a survey of North American patients","volume":"32","author":"Coleman M","year":"1988","journal-title":"J Ment Defic Res"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/088307388600100208"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(84)80030-3"},{"key":"e_1_2_1_12_2","first-page":"234","article-title":"Rett syndrome: clinical profile and EEG abnormalities","volume":"11","author":"Ho HH","year":"1988","journal-title":"Clin Invest Med"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250507"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1986.02140220043029"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(86)90072-6"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(87)80067-0"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1901\/jaba.1982.15-565"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.84.4.767"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250512"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.11.1434"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250509"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-198803000-00003"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/088307388800300109"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073888003001S03"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250528"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/088307388800300406"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02098506"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(87)80079-7"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198510103131504"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250109"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(85)80043-7"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(85)80044-9"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80060-X"},{"key":"e_1_2_1_34_2","first-page":"305","article-title":"Rett syndrome: positron emission tomography: metabolic\u2010clinical correlates","volume":"24","author":"Naidu S","year":"1988","journal-title":"Ann Neurol"},{"key":"e_1_2_1_35_2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0022-3565(25)21630-5","article-title":"Behavioral differences between neonatal and adult 6\u2010hydroxydopamine\u2010treated rats to dopamine agonists: Relevance to neurological symptoms in clinical syndromes with reduced brain dopamine","volume":"231","author":"Breese GR","year":"1984","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.870050303","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.870050303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:44:16Z","timestamp":1760960656000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.870050303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1002\/mds.870050303"],"URL":"https:\/\/doi.org\/10.1002\/mds.870050303","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}