{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:45:51Z","timestamp":1761007551525,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":4668,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of two drugs upon multifocal myoclonic jerks was evaluated. The drugs influence the central cholinergic system in opposite ways. Eight patients with progressive and nonprogressive myoclonic epilepsy were tested. The single blind test was used. The number of myoclonic jerks after intravenous physostigmine (mean dose 0.02 mg\/kg) and that after atropine (0.04 mg\/kg) was compared to number of myoclonic jerks in the drug\u2010free periods and with placebo. Placebo was without an effect. Physostigmine slightly increased the number of jerks. Atropine decreased the number significantly. In most patients the results were not striking. It is suggested that the cholinergic system may participate in the physiopathology of the studied myoclonic in a rather indirect, perhaps modulating way.<\/jats:p>","DOI":"10.1002\/mds.870070306","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T07:56:07Z","timestamp":1104566167000},"page":"224-227","source":"Crossref","is-referenced-by-count":2,"title":["Influence of cholinergic system on myoclonus in myoclonic epilepsies"],"prefix":"10.1002","volume":"7","author":[{"given":"Ivan","family":"Rektor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milada","family":"\u0160vejdov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Silva\u2010Barrat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Menini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-198506000-00001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.502"},{"key":"e_1_2_1_4_2","first-page":"115","article-title":"Analyse pharmacologique d'un nouveau cas de myoclonies d' intention et d'action post\u2010anoxique","volume":"126","author":"Lhermitte F","year":"1972","journal-title":"Rev Neurol"},{"key":"e_1_2_1_5_2","first-page":"323","article-title":"Approche pharmacologique et biochimique d'un syndrome de myoclonie d'action et d'intention au cours d'une affection degenerative du systeme nerveux","volume":"128","author":"Rohmer F","year":"1973","journal-title":"Rev Neurol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.25.2.135"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-198406000-00004"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.4.608"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870020202"},{"key":"e_1_2_1_10_2","first-page":"3","article-title":"Les myoclonies","volume":"142","author":"Menini C","year":"1986","journal-title":"Rev Neurol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(84)90356-2"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(86)90021-X"},{"key":"e_1_2_1_13_2","first-page":"263","volume-title":"Parkinson disease and movement disorders","author":"Obeso JA","year":"1988"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870040104"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870040103"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870030306"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.40.3.253"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.870070306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.870070306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:17:33Z","timestamp":1760969853000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.870070306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1002\/mds.870070306"],"URL":"https:\/\/doi.org\/10.1002\/mds.870070306","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}