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Although the involvement of similar neurotoxins has been implicated in PD, the etiology of the disease remains obscure. However, the recently described pathology of PD supports the view for a state of oxidative stress in the substantia nigra (SN), resulting as a consequence of the selective accumulation of iron in SN zone compacta and within the melanized dopamine neurons. Whether iron is directly involved cannot be ascertained. Nevertheless, the biochemical changes due to oxidative stress resulting from tisue iron overload (siderosis) are similar to those now being identified in parkinsonian SN. These include the reduction of mitochondrial electron transport, complex I and III activities, glutathione peroxidase activity, glutathione (GSH) ascorbate, calcium\u2010 binding protein, and superoxide dismutase and increase of basal lipid peroxidation and deposition of iron. The participation of iron\u2010 induced oxygen free radicals in the process of nigrostriatal dopamine neuron degeneration is strengthened by recent studies in which the neurotoxicity of 6\u2010 OHDA has been linked to the release of iron from its binding sites in ferritin. This is further supported by experiments with the prototypeiron chelator, desferrioxamine (Desferal), a free\u2010 radical inhibitor, which protects against 6\u2010 OHDA\u2010 induced lesions in the rat. Indeed, intranigral iron injection in rats produces a selective lesioning of dopamine neurons, resulting in a behavioral and biochemical parkinsonism.<\/jats:p>","DOI":"10.1002\/mds.870080102","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T10:06:12Z","timestamp":1104487572000},"page":"1-12","source":"Crossref","is-referenced-by-count":249,"title":["The possible role of iron in the etiopathology of parkinson's disease"],"prefix":"10.1002","volume":"8","author":[{"given":"M. B. 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