{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:52:05Z","timestamp":1761807125190,"version":"build-2065373602"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":4302,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the tremolytic effect of long\u2010acting propranolol (propranolol\u2010LA) in six subjects with drug\u2010induced parkinsonism (DIP), using a double\u2010blind, placebo\u2010controlled, crossover experimental design. Subjects received propranolol\u2010LA for 2 weeks and placebo for 2 weeks, with no change in neuroleptic treatment. Tremor frequency and amplitude were objectively quantified at the end of each 2\u2010week period by computerized tremorgram recording. There were no significant differences in attenuation of DIP tremor by propranolol\u2010 LA and placebo. Previous investigations reported in the literature have found propranolol to attenuate the tremor of idiopathic parkinsonism (IPD). It is expected that DIP and IPD tremor would respond similarly to propranolol if a solely peripheral or spinal cord tremolytic action were operative. A possible differential attenuation of IPD tremor and DIP tremor provides support for the concept of a higher central tremolytic mechanism of \u03b2\u2010adrenergic receptor\u2010blocking drugs.<\/jats:p>","DOI":"10.1002\/mds.870080108","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T10:06:12Z","timestamp":1104487572000},"page":"43-46","source":"Crossref","is-referenced-by-count":10,"title":["Inefficacy of propranolol in attenuation of drug\u2010induced parkinsonian tremor"],"prefix":"10.1002","volume":"8","author":[{"given":"W. Steven","family":"Metzer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen R.","family":"Paige","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph E. O.","family":"Newton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1962.00450190007002"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1982.00510220042009"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-349-06757-2_17"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)90746-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(65)92279-8"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160412"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1987.00520210023013"},{"key":"e_1_2_1_9_2","first-page":"416","volume-title":"Neurological anatomy","author":"Brodal A.","year":"1981"},{"key":"e_1_2_1_10_2","first-page":"205","volume-title":"Basic neurochemistry, ed. 3","author":"Coyle JT","year":"1981"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.870080108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.870080108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:22:07Z","timestamp":1760952127000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.870080108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/mds.870080108"],"URL":"https:\/\/doi.org\/10.1002\/mds.870080108","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}