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The larger dose of 0.5 mg\/kg produced a singificant increase in locomotion in three of four animals. A second group of eight monkeys also previously rendered parkinsonian by MPTP and having received no other treatment were given a daily treatment of bromocriptine 1.66 mg\/kg orally daily during 4 weeks. In four of the animals, after a week on bromocriptine alone, the D1 agonist CY 208\u2013243 was added in increasing doses of 0.05, 0.1, and 0.5 mg\/kg. The motor response as measured by locomotion, hand dexterity, and a disability score improved progressively at least in some of the animals on bromocriptine alone. The addition of CY 208\u2013243 produced a more striking improvement of all three parameters, which appeared to be dose dependent. Biochemical analysis of the brain of these animals plus one control and one MPTP untreated monkey showed a&lt;90% loss of dopamine in the striatum in six of the eight treated monkeys. Both D2 and D1 dopamine receptors were increased in density by denervation, but both treatments abolished this increase for the D2 receptors while increasing the affinity of the D1 receptors.<\/jats:p>","DOI":"10.1002\/mds.870080205","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T10:06:57Z","timestamp":1104487617000},"page":"144-150","source":"Crossref","is-referenced-by-count":40,"title":["Effect of adding the D1 agonist CY 208\u2013243 to chronic bromocriptine treatment. I: Evaluation of motor parameters in relation to striatal catecholamine content and dopamine receptors"],"prefix":"10.1002","volume":"8","author":[{"given":"Baltazar","family":"Gomez\u2010Mancilla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Boucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Gagnon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Th\u00e9r\u00e8se","family":"Di Paolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Markstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"B\u00e9dard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"11","article-title":"Neurochemical pathology of Parkinson's disease: basic facts and hypothetical possibilities","volume":"55","author":"Hornykiewicz O.","year":"1988","journal-title":"Mt Sinai J Med"},{"key":"e_1_2_1_3_2","first-page":"169","volume-title":"Therapy of Parkinson's disease","author":"Quinn PN","year":"1989"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(81)90346-1"},{"key":"e_1_2_1_5_2","first-page":"255","volume-title":"Recent developments in Parkinson's disease","author":"Calne DB","year":"1986"},{"key":"e_1_2_1_6_2","first-page":"339","volume-title":"Recent developments in Parkinson's disease","author":"Jankovic J.","year":"1986"},{"key":"e_1_2_1_7_2","first-page":"347","volume-title":"Recent developments in Parkinson's disease","author":"LeWitt PA","year":"1986"},{"key":"e_1_2_1_8_2","first-page":"267","volume-title":"Recent developments in Parkinson's disease","author":"Rinne UK","year":"1986"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.42.2.143"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.44.11.1020"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90783-3"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(90)90642-J"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1985.tb08863.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(85)90037-0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.10.1592"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(89)90358-3"},{"key":"e_1_2_1_17_2","first-page":"59","volume-title":"Progress in catecholamine research part B","author":"Markstein R","year":"1988"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(88)90322-6"},{"key":"e_1_2_1_19_2","unstructured":"B\u00e9dardPJ Gomez\u2010MancillaB BoucherR Di PaoloT.Pharmacological strategies in Parkinson's disease based on work in MPTP\u2010treated monkeys. 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