{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:26:53Z","timestamp":1761006413721,"version":"build-2065373602"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":4302,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Huntington's Disease Activities of Daily Living (HD\u2013ADL) scale is a 17\u2010item informant\u2010completed instrument for rating adaptive functioning in Huntington's disease (HD) patients. To assess the reliability and clinical correlates of the HD\u2013ADL, it was administered along with the Mini\u2010Mental State Exam (MMSE) and Quantified Neurological Exam (QNE) to 93 HD patients. The HD\u2010ADL has high internal consistency (coefficient alpha = 0.91). Principal components factor analysis of the HD\u2010ADL revealed four factors (General Functioning, Domestic Activities, Home Upkeep, and Family Relationships) accounting for 72% of the total variance. MMSE score, motor impairment score, and duration of disease were the best predictors of HD\u2010ADL score. Similar results were obtained in an independent replication sample of patients. The HD\u2010ADL scores correlate with Shoulson and Fahn's total functional capacity (TFC) index (<jats:italic>r<\/jats:italic> = \u22120.89). The HD\u2010ADL scale is a reliable and valid instrument for assessing adaptive function in HD patients.<\/jats:p>","DOI":"10.1002\/mds.870080212","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T10:06:57Z","timestamp":1104487617000},"page":"183-190","source":"Crossref","is-referenced-by-count":47,"title":["Assessment of adaptive functioning in huntington's disease"],"prefix":"10.1002","volume":"8","author":[{"given":"Frederick W.","family":"Bylsma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Rothlind","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle R.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan E.","family":"Folstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200613"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.3.341"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.1.1"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.10.1333"},{"key":"e_1_2_1_6_2","first-page":"15","article-title":"Huntington's disease: cognitive and psychiatric features","volume":"3","author":"Shoulson I.","year":"1990","journal-title":"Neuropsychiatry Neuropsychol Behav Neurology"},{"key":"e_1_2_1_7_2","first-page":"271","volume-title":"Quantification of Neurologic Deficit","author":"Shoulson I","year":"1989"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/01688638408401231"},{"volume-title":"Huntington's Disease; A Disorder of Families","year":"1989","author":"Folstein SE","key":"e_1_2_1_9_2"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.10.1279"},{"key":"e_1_2_1_11_2","first-page":"168","article-title":"Huntington's disease in Maryland: clinical aspects of racial variation","volume":"41","author":"Folstein SE","year":"1987","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_12_2","first-page":"605","article-title":"The measurement of abnormal movement: methods developed for Huntington's disease","volume":"5","author":"Folstein SE","year":"1983","journal-title":"Neurobehav Toxicol Teratology"},{"key":"e_1_2_1_13_2","first-page":"277","volume-title":"Movement Disorders","author":"Shoulson I.","year":"1983"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.10.1259"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.870080212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.870080212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:56:00Z","timestamp":1760950560000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.870080212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/mds.870080212"],"URL":"https:\/\/doi.org\/10.1002\/mds.870080212","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}