{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T08:39:07Z","timestamp":1775291947617,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":4302,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hereditary essential tremor (ET) is an autosomal dominant disorder with variable expression and reduced penetrance. A tremor indistinguishable from ET may be observed in patients with autosomal dominant idiopathic torsion dystonia (ITD), in which the disease locus has been mapped to 9q32\u201334 in some kindreds, tightly linked to the argininosuccinate synthetase (ASS) locus. We performed linkage analysis in 15 families with ET containing 60 definitely affected individuals, using dinucleotide repeat polymorphisms at the ASS locus and the Abelson locus (ABL). Cumulative lod scores were \u2212 19.5 for ASS and \u2212 10.8 for ABL at a recombination fraction of 0.01, and tight linkage to ASS was excluded individually in 11 of the families. These data indicate that the ET gene is not allelic to that causing ITD.<\/jats:p>","DOI":"10.1002\/mds.870080324","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T10:07:02Z","timestamp":1104487622000},"page":"374-376","source":"Crossref","is-referenced-by-count":27,"title":["Linkage analysis with chromosome 9 markers in hereditary essential tremor"],"prefix":"10.1002","volume":"8","author":[{"given":"D.","family":"Conway","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. G.","family":"Bain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. T.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. B.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. J.","family":"Findley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. D.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. D.","family":"Marsden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E.","family":"Harding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.35.3.365"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.7.1194"},{"key":"e_1_2_1_4_2","unstructured":"FindleyLJ KollerWJ De WittP et al. Classification and defintion of tremor.World Neurol(in press)."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/72.2.113"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.32.6.509"},{"key":"e_1_2_1_7_2","first-page":"343","article-title":"Tremblement idiopathique de repos, d'attitude et d'action. Etude anatamo\u2010clinique d'une observation","volume":"130","author":"Lapresle J","year":"1974","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.9.1422"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/97.1.793"},{"key":"e_1_2_1_10_2","first-page":"245","volume-title":"Dystonia","author":"Couch JR","year":"1976"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/105.3.461"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.48.6.545"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.20.11_Part_2.1"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.12.1.12"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.21.1.13"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/113.2.379"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870060406"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90188-8"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270203"},{"issue":"2","key":"e_1_2_1_20_2","first-page":"99","article-title":"Linkage analysi in British families with idiopathic torsion dystonia","volume":"239","author":"Warner T","year":"1992","journal-title":"J Neuro"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.2.225"},{"key":"e_1_2_1_22_2","first-page":"121","article-title":"Ident fication of a highly polymorphic microsatellite VNTR within the argininosuccinate synthetase locus: exclusion of the dystonia gene on 9q32\u201034 as the cause of dopa\u2010responsive dystonia in a large kindred","volume":"48","author":"Kwiatkowski DJ","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_23_2","first-page":"967","article-title":"Dinucleotide repeat polymorphism at the ABL locus (9q34)","volume":"19","author":"Kwiatkowski DJ","year":"1991","journal-title":"Nucleic Acids Res"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.870080324","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.870080324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:28:29Z","timestamp":1760963309000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.870080324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/mds.870080324"],"URL":"https:\/\/doi.org\/10.1002\/mds.870080324","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}