{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:11:53Z","timestamp":1785435113116,"version":"3.56.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":4302,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lubag is an x\u2010linked recessive dystonia parkinsonism that affects Filipino men originating principally from the Panay Island. Linkage analysis has confirmed the mode of inheritance and localized the disease gene to the proximal long arm of the x\u2010chromosome. We studied the brain of a 34 year old Filipino man affected with lubag. He developed truncal dystonia at age 30, which subsequently generalized. With disease progression, he also presented with parkinsonism including, rigidity, bradykinesia, and impaired balance. His symptoms were largely unaffected by medication and, at age 34, he underwent a right cryothalamotomy. He died suddenly 2 days after the procedure. The principal neuropathological findings were neuronal loss and a multifocal mosaic pattern of astrocytosis restricted to the caudate and lateral putamen. Similar findings have been reported in two other men with dystonia\u2013one Filipino and the other non\u2010Filipino. The similar pathology of the two Filipino men suggests that this is the pathology of lubag. Recognition of this pathology in a non\u2014Filipino man suggests that the mutation causing lubag may not be restricted to the Filipino population.<\/jats:p>","DOI":"10.1002\/mds.870080328","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T10:07:02Z","timestamp":1104487622000},"page":"387-390","source":"Crossref","is-referenced-by-count":98,"title":["Neuropathology of lubag (x\u2010linked dystonia parkinsonism)"],"prefix":"10.1002","volume":"8","author":[{"given":"C. H.","family":"Waters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. L.","family":"Faust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Powers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Vinters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Moskowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nygaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Fahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"137","article-title":"Torsion dystonia in Panay, Philippines","volume":"14","author":"Lee LV","year":"1976","journal-title":"Adv Neurol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290203"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199105000-00002"},{"key":"e_1_2_1_5_2","first-page":"424","article-title":"Clinical expression of lubag (X\u2010Linked Dystonia\u2010Parkinsonism) in two women. [Abstract]","volume":"42","author":"Waters CH","year":"1992","journal-title":"Neurology"},{"key":"e_1_2_1_6_2","first-page":"363","article-title":"Refinement of the pericentromeric localization of lubag (X\u2010linked dystonia\u2010parkinsonism) [Abstract]","volume":"49","author":"Nygaard TG","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_7_2","first-page":"808","article-title":"Dystonia\u2010parkinsonism syndrome (XDP) locus: flanking markers in Xq12\u2010q21. 1","volume":"50","author":"Kupke KG","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.20.11_Part_2.79"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.33.4.457"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.44.5.437"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198701293160515"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870030305"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.5.702"},{"issue":"1","key":"e_1_2_1_14_2","first-page":"399","article-title":"Lewy bodies in Meige's syndrome [Abstract]","volume":"40","author":"Mark MH","year":"1990","journal-title":"Neurology"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.6.802"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870070305"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1972.00490120046004"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.962"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.47.7.704"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150303"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/108.2.463"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.48.7.650"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.7.1125"},{"key":"e_1_2_1_24_2","first-page":"288","article-title":"The primary site of dopamine neuron damage in Parkinson's disease: substantia nigra or striatum?","volume":"7","author":"Hornykiewicz O.","year":"1992","journal-title":"Mov Disord"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.870080328","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.870080328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:28:34Z","timestamp":1760963314000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.870080328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/mds.870080328"],"URL":"https:\/\/doi.org\/10.1002\/mds.870080328","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}