{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:26:40Z","timestamp":1790789200532,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":3937,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe the time course of and pharmacology associated with auditory\u2010induced muscle jerks following cardiac arrest in rats. The data indicate that several key features of this model mimic those of human posthypoxic myoclonus. Similar to the human form, the muscle jerks appear in the rats following an acute hypoxic episode (cardiac arrest). Initially, it is known that both spontaneous and auditory\u2010induced myoclonus are present in these animals; some cardiac\u2010arrested rats also exhibit seizures. Over the first few days after the arrest, episodes of both the seizure activity and spontaneous myoclonus disappear. The auditory\u2010induced myoclonus continues to worsen, reaches a peak about 2 weeks after the arrest, then declines over time to subnormal levels. The auditory\u2010induced muscle jerks exhibited by the cardiac arrested animals are attenuated by the typical antimyoclonic drugs 5\u2010hydroxytryptophan, valproic acid, and clonazepam. In addition, the novel anticonvulsant felbamate was found to have antimyoclonic properties. The data suggest that this rat cardiac arrest model may be a valuable tool for investigating the pathophysiologic mechanisms of posthypoxic myoclonus and for developing new therapeutic strategies for treating the disorder.<\/jats:p>","DOI":"10.1002\/mds.870090214","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T11:35:19Z","timestamp":1104492919000},"page":"201-206","source":"Crossref","is-referenced-by-count":45,"title":["Novel rat cardiac arrest model of posthypoxic myoclonus"],"prefix":"10.1002","volume":"9","author":[{"given":"Daniel D.","family":"Truong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rae R.","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip H.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Hussong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude G.","family":"Wasterlain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"157","article-title":"Posthypoxic action myoclonus literature review update","volume":"43","author":"Fahn S","year":"1986","journal-title":"Adv Neurol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1968.tb27517.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/86.1.111"},{"key":"e_1_2_1_5_2","first-page":"49","article-title":"Postanoxic action myoclonus review of the literature and report of two new cases with response to valproate and estrogen","volume":"26","author":"Fahn S","year":"1979","journal-title":"Adv Neurol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.40.3.253"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.8.1107"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.3.401"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1991.tb04686.x"},{"key":"e_1_2_1_10_2","first-page":"171","article-title":"Biochemistry and therapeutics of posthypoxic myoclonus","volume":"43","author":"Van Woert MH","year":"1986","journal-title":"Adv Neurol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(72)90064-6"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870060203"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1096\/fasebj.4.10.2165010","article-title":"Disorder of the inhibitory glycine receptor inherited myoclonus in Poll Hereford calves","volume":"4","author":"Gundlach AL","year":"1990","journal-title":"FASEB J"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.10.1020"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1990.tb04153.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(70)90133-2"},{"key":"e_1_2_1_17_2","first-page":"173","article-title":"Animal models of myoclonus","volume":"26","author":"Van Woert MH","year":"1979","journal-title":"Adv Neurol"},{"key":"e_1_2_1_18_2","first-page":"101","article-title":"Experimental urea\u2010induced myoclonic seizures mechanism and site of action","volume":"96","author":"Zuckermann EC","year":"1971","journal-title":"Trans Am Neurol Assoc"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1985.57"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410110509"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00690397"},{"key":"e_1_2_1_22_2","unstructured":"SchwartzPH. An adult and a neonatal model of cerebral ischemia participation of excitotoxic mechanisms. Ph.D. thesis Los Angeles: University of California 1992."},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197808102990621"},{"key":"e_1_2_1_24_2","first-page":"107","article-title":"Analyse pharmacologique d'un nouveau cas de myoclonies d'intention et d'action post\u2010anoxiques","volume":"126","author":"L'hermitte F","year":"1972","journal-title":"Rev Neurol Paris"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1992.tb01711.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(89)90072-5"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(85)90020-6"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199001000-00017"},{"key":"e_1_2_1_29_2","first-page":"661.9","article-title":"Behavioral, physiological and pharmacological aspects of stimulus\u2010sensitive post\u2010anoxic myoclonus in the rat","volume":"18","author":"Schwartz PH","year":"1992","journal-title":"Soc Neurosci Abst"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1037\/h0022318"},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/S0022-3565(25)10138-9","article-title":"Evidence for anticonvulsant and neuroprotectant action of felbamate mediated by strychnine\u2010insensitive glycine receptors","volume":"264","author":"McCabe T","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1991.tb04695.x"},{"key":"e_1_2_1_33_2","first-page":"687","article-title":"Drugs acting on amino acid neurotransmitters","volume":"43","author":"Meldrum BS","year":"1986","journal-title":"Adv Neurol"},{"key":"e_1_2_1_34_2","volume-title":"Multiple sigma and PCP receptor ligands","author":"Kamenka J\u2010M","year":"1992"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199301073280105"},{"key":"e_1_2_1_36_2","first-page":"642","article-title":"Felbamate serum concentrations effect of valproate, carbamazepine, phenytoin, and phenobarbital","volume":"31","author":"Wagner ML","year":"1990","journal-title":"Epilepsia"},{"key":"e_1_2_1_37_2","first-page":"183","article-title":"Treatment of posthypoxic action myoclonus implications for the pathophysiology of the disorder","volume":"43","author":"Chadwick D","year":"1986","journal-title":"Adv Neurol"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00313141"},{"key":"e_1_2_1_39_2","first-page":"629","article-title":"Mechanism of action of clonazepam in myoclonus in relation to effects on GABA and 5\u2010HT","volume":"43","author":"Jenner P","year":"1986","journal-title":"Adv Neurol"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.870090214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.870090214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:23:38Z","timestamp":1760970218000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.870090214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1002\/mds.870090214"],"URL":"https:\/\/doi.org\/10.1002\/mds.870090214","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}