{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:30:46Z","timestamp":1791333046615,"version":"4.3.1"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":3937,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>At present, the pharmacotherapy of Parkinson's disease (PD) consists mainly of L\u2010dihydroxyphenylalanine (L\u2010DOPA) and\/or dopamine D<jats:sub>2<\/jats:sub> receptor agonist. However, in general the clinical efficacy of D<jats:sub>2<\/jats:sub> agonists is less than that of L\u2010DOPA. Therefore, attention is being focussed on the role of the D<jats:sub>1<\/jats:sub> receptor as a target for therapeutic intervention in PD. Recently, we reported that SKF 81297 is a selective D<jats:sub>1<\/jats:sub> agonist that stimulates motor behavior of unilaterally MPTP (1\u2010methyl\u20104\u2010phenyl\u20101, 2, 3, 6\u2010tetrahydropyridine)\u2010lesioned rhesus monkeys. Presently, we studied the effect of coadministration of SKF 81297 and the D<jats:sub>2<\/jats:sub> agonist LY 171555 using the same model of PD. Coadministration of behaviorally active doses of SKF 81297 (0.3 mg\/kg) and LY 171555 (0.01 mg\/kg) resulted in a prolongation of the motor stimulation induced by either of the drugs alone. Neither administration of SKF 81297, in a dose of 0.03 mg\/kg, nor of LY 171555, in a dose of 0.003 mg\/kg, were behaviorally active, whereas the combined administration of these compounds induced a significant stimulation of motor behavior. These data suggest that (a) D<jats:sub>1<\/jats:sub> receptor stimulation will prove to be useful in the treatment of PD and (b) better therapeutic results will be obtained by simultaneous stimulation of D<jats:sub>1<\/jats:sub> and D<jats:sub>2<\/jats:sub> receptors as compared with stimulation of both receptors alone.<\/jats:p>","DOI":"10.1002\/mds.870090613","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T11:38:19Z","timestamp":1104493099000},"page":"664-672","source":"Crossref","is-referenced-by-count":39,"title":["The dopamine D<sub>1<\/sub> agonist SKF 81297 and the dopamine D<sub>2<\/sub> agonist LY 171555 act synergistically to stimulate motor behavior of 1\u2010methyl\u20104\u2010phenyl\u20101, 2, 3, 6\u2010tetrahydropyridine\u2010lesioned parkinsonian rhesus monkeys"],"prefix":"10.1002","volume":"9","author":[{"given":"R. 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