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The audiogenic posthypoxic myoclonus in these animals could be attenuated with the following drugs: 5\u2010hydroxytryptophan (5\u2010HTP, serotonin [5\u2010HT] precursor), N\u2010(3\u2010trifluoromethylphenyl) piperazine hydrochloride (TFMPP, 5\u2010HT1B\/1C\/2 agonist), (\u00b1)\u20102,5\u2010dimethoxy\u20104\u2010iodoamphetamine hydrobromide (DOI, 5\u2010HT2 agonist), and l\u2010(m\u2010chlorophenyl)\u2010biguanide hydrochloride (m\u2010CPBG, 5\u2010HT3 agonist). In contrast, the following drugs were ineffective: (\u00b1)\u20108\u2010hydroxy\u2010dipropylaminottetralin hydrobromide (8\u2010OH\u2010DPAT, 5\u2010HT1A agonist), buspirone hydrochoride (5\u2010HT1A agonist), 7\u2010trifluoromethyl\u20104(4\u2010methyl\u20101\u2010piperazinyl)\u2010pyrrolo[1,2\u2010a]quinoxaline maleate (CGS 12066B, 5\u2010HT1B agonist), ketanserin tartrate (5\u2010HT2 antagonist), methysergide maleate (5\u2010HT2 antagonist), fluoxetine (5\u2010HT uptake blocker), and saline (vehicle). The data suggest that enhancement of serotonergic activity, particularly through 5\u2010HT2 and 5\u2010HT3 receptors, have therapeutic potential for the treatment of posthypoxic myoclonus.<\/jats:p>","DOI":"10.1002\/mds.870100514","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T09:43:25Z","timestamp":1104486205000},"page":"615-621","source":"Crossref","is-referenced-by-count":11,"title":["Effects of selective serotonergic ligands on posthypoxic audiogenic myoclonus"],"prefix":"10.1002","volume":"10","author":[{"given":"Rae R.","family":"Matsumoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Hussong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel 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