{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:30:13Z","timestamp":1761006613114,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,11,4]],"date-time":"2004-11-04T00:00:00Z","timestamp":1099526400000},"content-version":"vor","delay-in-days":3230,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In situ hybridization histochemistry was used to investigate the expression of striatal preproenkephalin and preprotachykinin messenger ribonucleic acid (mRNA) in rats with 6\u2010hydroxydopamine lesions of the nigrostriatal pathway followed 4 weeks later by implantation of foetal dopamine cells into the denervated striatum. Striatal dopamine deafferentation caused an (+)\u2010amphetamine\u2010induced rotational asymmetry, an increase in striatal preproenkephalin mRNA message, and a decrease in striatal preprotachykinin mRNA message relative to control animals. Two months after grafting a foetal ventral mesencephalon suspension, there was reversal of the rotational asymmetry to (+)\u2010amphetamine. At this time the increase in striatal preproenkephalin mRNA was significantly attenuated and the decrease in preprotachykinin mRNA was partially reversed compared to animals with a 6\u2010hydroxydopamine lesion alone. Subregional analysis showed the attenuation of the increase in preproenkephalin mRNA to occur in dorsolateral, dorsomedial and ventromedial, but not ventrolateral, striatal subdivisions. The partial reversal of the decreased preprotachykinin mRNA density after grafting was only statistically significant in the DM and VM subdivisions. These results demonstrate graft\u2010induced partial recovery of striatal function, as judged by preproenkephalin and preprotachykinin mRNA levels, within 2 months of transplantation.<\/jats:p>","DOI":"10.1002\/mds.870110109","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T09:44:14Z","timestamp":1104486254000},"page":"43-52","source":"Crossref","is-referenced-by-count":1,"title":["Partial reversal of increased preproenkephalin messenger ribonucleic acid (mRNA) and decreased preprotachykinin mRNA by foetal dopamine cells in unilateral 6\u2010Hydroxydopamine\u2013Lesioned rat striatum parallels functional recovery"],"prefix":"10.1002","volume":"11","author":[{"given":"B.\u2010Y.","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Jenner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. D.","family":"Marsden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90498-4"},{"key":"e_1_2_1_3_2","first-page":"29","article-title":"Intracerebral grafting of neuronal suspensions. IV. Behavioural recovery in rats with unilateral 6\u2010OHDA lesions following implantation of nigral cell suspensions in different forebrain sites","volume":"522","author":"Dunnett SB","year":"1983","journal-title":"Acta Physiol Scand"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(87)90207-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(89)90139-8"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-03-00603.1985"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(91)90095-T"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90159-Y"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90074-X"},{"key":"e_1_2_1_10_2","first-page":"155","volume-title":"Handbook of physiology\u2010the nervous system, IV","author":"Bjorklund A","year":"1986"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90104-I"},{"key":"e_1_2_1_12_2","first-page":"427","volume-title":"Chemical neuroanatomy","author":"Graybiel AM","year":"1989"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(90)90003-7"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1987.tb01036.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)91149-8"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(92)90004-U"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(92)90068-M"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.113050"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1988.tb01100.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90386-3"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(93)90193-S"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1993.1001"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90062-K"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00574-O"},{"volume-title":"A stereotaxic atlas of the rat brain","year":"1979","author":"Pellegrino LJ","key":"e_1_2_1_25_2"},{"key":"e_1_2_1_26_2","first-page":"1","article-title":"Intracerebral grafting of neuronal cell suspensions I. Introduction and general methods of preparation","volume":"522","author":"Bjorklund A","year":"1983","journal-title":"Acta Physiol Scand"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90692-7"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91316-8"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90269-1"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.24.9827"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(91)90050-T"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(78)90011-4"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90552-1"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(90)90227-Q"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(91)90011-L"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902730104"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90134-A"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1992.tb00175.x"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.1.230"},{"key":"e_1_2_1_40_2","first-page":"489","article-title":"Neuropeptide gene expression is differentially regulated by midbrain dopamine neurons","volume":"80","author":"Lindefor N","year":"1990","journal-title":"Exp Brain Res"},{"key":"e_1_2_1_41_2","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1523\/JNEUROSCI.11-04-01016.1991","article-title":"Dopamine differentially regulates dynorphin, substance P, and enkephalin expression in striatal neurons: in situ hybridization histo\u2010chemical analysis","volume":"11","author":"Gerfen CR","year":"1991","journal-title":"J Neurosci"},{"key":"e_1_2_1_42_2","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/S0022-3565(25)23781-8","article-title":"Striatal tachykinin gene expression regulated by interaction of D1 and D2 dopamine receptors","volume":"248","author":"Haverstick DM","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00247354"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90759-9"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)91153-2"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1037\/h0036152"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.870110109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.870110109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:39:24Z","timestamp":1760953164000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.870110109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["10.1002\/mds.870110109"],"URL":"https:\/\/doi.org\/10.1002\/mds.870110109","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[1996,1]]}}}