{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:30:39Z","timestamp":1761006639525,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,11,4]],"date-time":"2004-11-04T00:00:00Z","timestamp":1099526400000},"content-version":"vor","delay-in-days":3230,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The motor effects of the short\u2010acting, full D<jats:sub>1<\/jats:sub> agonist SKF 82958 were studied in three drug\u2010naive, 1\u2010methyl\u20104\u2010phenyl\u20101, 2, 3, 6\u2010tetrahydropyridine\u2010lesioned, parkinsonian monkeys treated for 4 weeks. D<jats:sub>1<\/jats:sub> receptor stimulation with SKF 82958 effectively relieved parkinsonism but induced choreic dyskinesia (n = 2) and a shorter duration of motor benefit (n = 3) over time. Isolated, short\u2010lived D<jats:sub>1<\/jats:sub> receptor activation would not appear to confer advantage over levodopa for dyskinesia prevention. Our data also support the involvement of postsynaptic dopamine receptor mechanisms in the wearing\u2010off phenomenon seen in levodopa\u2010treated parkinsonian patients.<\/jats:p>","DOI":"10.1002\/mds.870110117","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T09:44:14Z","timestamp":1104486254000},"page":"91-94","source":"Crossref","is-referenced-by-count":57,"title":["Dyskinesia and wearing\u2010off following dopamine D<sub>1<\/sub> agonist treatment in drug\u2010naive 1\u2010Methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine\u2010lesioned primates"],"prefix":"10.1002","volume":"11","author":[{"given":"P. J.","family":"Blanchet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Grondin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"B\u00e9dard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90783-3"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/S0022-3565(25)38236-4","article-title":"Relative potency and efficacy of some dopamine agonists with varying selectivities for D1 and D2 receptors in MPTP\u2010induced hemiparkinsonian monkeys","volume":"265","author":"Domino EF","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0022-3565(25)39350-X","article-title":"Differential effect of selective D\u20101 and D\u20102 dopamine receptor agonists on levodopa\u2010induced dyskinesia in MPTP monkeys","volume":"267","author":"Blanchet P","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870070309"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0922-4106(93)90007-V"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0922-4106(90)90194-3"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.6.927"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90222-7"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90694-I"},{"key":"e_1_2_1_11_2","first-page":"113","article-title":"Role of selective D1 and D2 agonists in inducing dyskinesia in drug\u2010naive MPTP monkeys","volume":"60","author":"B\u00e9dard PJ","year":"1993","journal-title":"Adv Neurol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2147780"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100047909"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870050203"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410240303"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(89)90372-9"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.7.949"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360108"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91331-8"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00229-J"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.870110117","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.870110117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:39:13Z","timestamp":1760953153000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.870110117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["10.1002\/mds.870110117"],"URL":"https:\/\/doi.org\/10.1002\/mds.870110117","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[1996,1]]}}}